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The evolution of modularity in genome architecture (2000).
| Content Provider | CiteSeerX |
|---|---|
| Author | Santa, John Pepper |
| Abstract | It has been suggested that the capacity to evolve can itself evolve. One factor that may be important in determining evolvability is modularity of the genotype-phenotype map. A related phenomenon is modularity in genome architecture, in which genes with epistatic effects are colocalized on the chromosome. This changes a population's response to recombination by maximizing recombination among genes with additive effects and minimizing recombination of genes with epistatic interactions. The effects and origins of genome modularity were investigated using a computational model, in which a population of individuals evolved in a changing fitness landscape under mutation and recombination. Populations with modular genomes evolved faster than did populations with non-modular genomes. Moreover, in long runs that started with nonmodular genomes but allowed inversion, populations evolved high levels of genome modularity. This demonstrates that over long time periods, evolvabili... |
| File Format | |
| Publisher Date | 2000-01-01 |
| Access Restriction | Open |
| Subject Keyword | Genome Architecture Genome Modularity Long Run High Level Related Phenomenon Non-modular Genome Long Time Period Nonmodular Genome Epistatic Interaction Fitness Landscape Additive Effect Epistatic Effect Genotype-phenotype Map Computational Model Modular Genome |
| Content Type | Text |
