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andWong L, Increasing confidence of protein-protein inteactomes (2006)
| Content Provider | CiteSeerX |
|---|---|
| Author | Chua, Jin Chen Hon Nian |
| Description | High-throughput experimental methods, such as yeast-two-hybrid and phage display, have fairly high levels of false positives (and false negatives). Thus the list of protein-protein interactions detected by such experiments would need additional wet laboratory validation. It would be useful if the list could be prioritized in some way. Advances in computational techniques for assessing the reliability of protein-protein interactions detected by such high-throughput methods are reviewed in this paper, with a focus on techniques that rely only on topological information of the protein interaction network derived from such high-throughput experiments. In particular, we discuss indices that are abstract mathematical characterizations of networks of reliable protein-protein interactions—e.g., “interaction generality ” (IG), “interaction reliability by alternatve pathways” (IRAP), and “functional similarity weighting ” (FSWeight). We also present indices that are based on explicit motifs associated with true-positive protein interactions—e.g., “new interaction generality” (IG2) and “meso-scale motifs ” (NeMoFinder). Keywords: Protein-protein interaction network, graph mining, network motif. 1 |
| File Format | |
| Language | English |
| Publisher Date | 2006-01-01 |
| Publisher Institution | In Proc. of 17th International Conference on Genome Informatics |
| Access Restriction | Open |
| Subject Keyword | Present Index Protein Interaction Network New Interaction Generality Meso-scale Motif Protein-protein Interaction Network Protein-protein Interaction High Level False Negative Abstract Mathematical Characterization Functional Similarity Weighting Additional Wet Laboratory Validation Topological Information High-throughput Experiment Interaction Generality Graph Mining Protein-protein Inteactomes Interaction Reliability Computational Technique High-throughput Experimental Method Alternatve Pathway Explicit Motif Reliable Protein-protein Interaction High-throughput Method True-positive Protein Interaction False Positive Network Motif Phage Display |
| Content Type | Text |
| Resource Type | Article |
