Protein synthesis-dependent formation of protein kinase Mzeta in long-term potentiation (1996)

Content Provider	CiteSeerX
Author	Osten, Pave Valsamis, Lengko Harris, Er Sacktor, Todd Chat-Ron
Abstract	The maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus has been reported to require both a persistent increase in phosphorylation and the synthesis of new proteins. The increased activity of protein kinase C (PKC) dur-ing the maintenance phase of LTP may result from the forma-tion of PKM&‘, the constitutively active fragment of a specific PKC isozyme. To define the relationship among PKMC, long-term EPSP responses, and the requirement for new protein synthesis, we examined the regulation of PKM< after sub-threshold stimulation that produced short-term potentiation (STP) and after suprathreshold stimulation by single and mul-tiple tetanic trains that produced LTP. We found that, although no persistent increase in PKM [ followed STP, the degree of
File Format	PDF
Volume Number	16
Journal	J. Neurosci
Language	English
Publisher Date	1996-01-01
Access Restriction	Open
Subject Keyword	Long-term Potentiation Protein Kinase Mzeta Protein Synthesis-dependent Formation Persistent Increase New Protein Specific Pkc Isozyme Mul-tiple Tetanic Train Active Fragment Protein Kinase Short-term Potentiation Ca1 Region Long-term Epsp Response New Protein Synthesis Sub-threshold Stimulation Suprathreshold Stimulation Maintenance Phase Increased Activity
Content Type	Text
Resource Type	Article