NDLI: A man with generalised lymphadenopathy (Published 12 December 2014)

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Acute nasal injury (Published 18 December 2014)

Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study (Published 02 December 2014)

“Human guinea pig” asks for animal studies (Published 30 December 2014)

Diagnosis and management of community and hospital acquired pneumonia in adults: summary of NICE guidance (Published 03 December 2014)

What I know I owe to patients (Published 01 December 2014)

Dannie Abse (Published 02 December 2014)

Mediterranean diet and telomere length (Published 02 December 2014)

Mixed worm infestation causing dysphagia (Published 03 December 2014)

Discontinuation and non-publication of surgical randomised controlled trials: observational study (Published 09 December 2014)

Intrapartum care of healthy women and their babies: summary of updated NICE guidance (Published 03 December 2014)

Do liberal blood transfusions cause more harm than good? (Published 05 December 2014)

The association between exaggeration in health related science news and academic press releases: retrospective observational study (Published 10 December 2014)

Are “armchair socialists” still sitting? Cross sectional study of political affiliation and physical activity (Published 11 December 2014)

Clinical trials: what a waste (Published 10 December 2014)

SearCh for humourIstic and Extravagant acroNyms and Thoroughly Inappropriate names For Important Clinical trials (SCIENTIFIC): qualitative and quantitative systematic study (Published 16 December 2014)

The Darwin Awards: sex differences in idiotic behaviour (Published 11 December 2014)

Healer, dealer, heart stealer: portrayals of the doctor in popular music (Published 11 December 2014)

Operating theatre time, where does it all go? A prospective observational study (Published 15 December 2014)

CARTOONS KILL: casualties in animated recreational theater in an objective observational new study of kids’ introduction to loss of life (Published 16 December 2014)

Transmissibility of the Ice Bucket Challenge among globally influential celebrities: retrospective cohort study (Published 16 December 2014)

Every contact is an opportunity to promote healthy lifestyles (Published 10 December 2014)

Using the term pre-cancer creates a new disease out of a risk factor (Published 02 December 2014)

Authors’ reply to Jewell (Published 02 December 2014)

The King Canute GP appointment system (Published 11 December 2014)

Testosterone replacement therapy and cardiovascular events (Published 02 December 2014)

Target diagnosis rates in primary care are misleading and unethical (Published 02 December 2014)

Stop wasting taxpayers’ money on management consultancy for the NHS (Published 10 December 2014)

Author’s reply to Hackett (Published 02 December 2014)

Alternatives to arteriovenous fistulas (Published 02 December 2014)

Authors’ reply to Corbett and colleagues (Published 02 December 2014)

When somebody loses weight, where does the fat go? (Published 16 December 2014)

Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial (Published 16 December 2014)

An exploration of the basis for patient complaints about the oldness of magazines in practice waiting rooms: cohort study (Published 11 December 2014)

Christmas dinner for doctors on duty: it’s grimmer up north (Published 18 December 2014)

Traction scarring alopecia masquerading as cranial surgery (Published 10 December 2014)

Can doctors be trained in a 48 hour working week? (Published 10 December 2014)

Exercise induced dyspnoea and other stories (Published 03 December 2014)

Licensed indication for risperidone in dementia (Published 10 December 2014)

“Personalising” NHS information technology in England (Published 02 December 2014)

English as she is mis-spoke, misread, and miswrote—or, why you should read before you sign (Published 18 December 2014)

Televised medical talk shows—what they recommend and the evidence to support their recommendations: a prospective observational study (Published 17 December 2014)

Ebola virus disease (Published 10 December 2014)

Great leap backwards (Published 02 December 2014)

Don’t forget the relatives (Published 03 December 2014)

Anatomy of a Care Quality Commission inspection (Published 01 December 2014)

Thomas Anthony Piers Clarke (Published 01 December 2014)

Brian Gerard Haggart (Published 01 December 2014)

Charles Robert Dundas (Published 01 December 2014)

Henry Alfred Milne (Published 01 December 2014)

Louis Solomon (Published 01 December 2014)

Christopher Michael Wragg (Published 01 December 2014)

Captain Webb’s legacy: the perils of swimming the English Channel (Published 16 December 2014)

Australia’s proposal for copayments is set to fail amid confusion (Published 01 December 2014)

Effect of pelvic floor muscle training compared with watchful waiting in older women with symptomatic mild pelvic organ prolapse: randomised controlled trial in primary care (Published 22 December 2014)

Medical training: some “forgotten” common competencies (Published 17 December 2014)

Diabetes in midlife increases cognitive decline 20 years later, study finds (Published 02 December 2014)

Sam Everington: Happiest on a Norwegian mountain farm (Published 03 December 2014)

Utility of Hippocrates’ prognostic aphorism to predict death in the modern era: prospective cohort study (Published 15 December 2014)

In brief (Published 03 December 2014)

Use of Google Translate in medical communication: evaluation of accuracy (Published 15 December 2014)

Antenatal and postnatal mental health: summary of updated NICE guidance (Published 18 December 2014)

Rethinking diagnostic delay in cancer: how difficult is the diagnosis? (Published 10 December 2014)

Physician, don’t heal thyself: the perils of self prescribing (Published 08 December 2014)

“The west African Ebola disaster has stretched us to near breaking point”: MSF’s volunteer doctors need your support (Published 03 December 2014)

Variations in lung cancer care continue to affect survival and quality of life (Published 03 December 2014)

Midwife led delivery is safer than a labour ward for low risk pregnancies, says NICE guidance (Published 03 December 2014)

A novel clinical entity: the Campbell-Trachter syndrome (Published 15 December 2014)

European Medicines Agency is accused of weakening its conflict of interest policy (Published 02 December 2014)

Doctors’ leaders applaud NHS cash injection (Published 02 December 2014)

Local government leaders almost walked away from Better Care Fund deal, MPs hear (Published 02 December 2014)

Making music in the operating theatre (Published 11 December 2014)

Legal action against rogue surgeon is suspended after MDU withdraws funding (Published 04 December 2014)

A man with generalised lymphadenopathy (Published 12 December 2014)

The milk debate, conflicts of interest, and our Christmas appeal (Published 04 December 2014)

The secret lives of the Bastion Bakers (Published 18 December 2014)

Mass flu vaccination of healthcare workers: not to be sniffed at (Published 10 December 2014)

High rates of associated morbidity and mortality justify flu vaccination (Published 10 December 2014)

Margaret McCartney: The Care Quality Commission is not fit for purpose (Published 12 December 2014)

Preventing bad reporting on health research (Published 10 December 2014)

Vivian Livingston (Published 05 December 2014)

Robert William Clark (Published 05 December 2014)

Carys Mair Graham (Published 05 December 2014)

Khushru Mancherji Mehta (Published 05 December 2014)

Henry Shapiro (Published 05 December 2014)

Margaret McCartney: Industry’s interest in diagnosing more dementia (Published 03 December 2014)

Imbalance of power between patients and doctors (Published 15 December 2014)

Cardiac defibrillators and other stories . . . (Published 10 December 2014)

What would an evidence based drug policy be like? (Published 09 December 2014)

Musical theatre (Published 19 December 2014)

Independent studies needed before expanding flu vaccination (Published 10 December 2014)

Alan Douglas Lower (Published 05 December 2014)

Randomised controlled trials: subgroup analyses (Published 05 December 2014)

Ronald Charles King (Published 05 December 2014)

How 21st century capitalism is failing us (Published 15 December 2014)

Another time: England, 1936 (Published 15 December 2014)

Savings from switching to bevacizumab for retinal disorders are underestimated (Published 10 December 2014)

Macular degeneration needs longer lasting treatments (Published 10 December 2014)

How MSF is mapping the world’s medical emergency zones (Published 09 December 2014)

A means of measuring serial changes in anal sphincter tone in patients with spinal cord compression (Published 16 December 2014)

Ameyo Adadevoh (Published 16 December 2014)

Gillian Leng: Pet hate is fixed opinions (Published 10 December 2014)

Regulator apologises to 60 general practices for wrongly prioritising them for inspection (Published 09 December 2014)

Ear pain, vesicular rash, and facial palsy (Published 10 December 2014)

In brief (Published 10 December 2014)

Most maternal deaths are caused by deterioration in unrelated medical conditions (Published 10 December 2014)

Medical eponyms: taxonomies, natural history, and the evidence (Published 16 December 2014)

Former journal editor had potential conflicts of interest in nine of 10 articles he authored (Published 09 December 2014)

Hospital beds stand empty in Liberia, while patients are turned away in Sierra Leone (Published 09 December 2014)

Iliopsoas cyst: rare cause of hip pain and vascular compression in osteoarthritis (Published 31 December 2014)

Drug policy: we need brave politicians and open minds (Published 10 December 2014)

A third of NHS contracts awarded since health act have gone to private sector, BMJ investigation shows (Published 10 December 2014)

Don’t look away now (Published 16 December 2014)

Doctors: caring extroverts or self deluded chocoholics? (Published 18 December 2014)

When locums can earn as much as partners, general practice is in trouble (Published 16 December 2014)

Travel related infections and other stories . . . (Published 31 December 2014)

Need for guidelines on body recontouring after bariatric surgery (Published 16 December 2014)

Tackling obesity among the medical profession (Published 16 December 2014)

GP funding formula masks major inequalities for practices in deprived areas (Published 16 December 2014)

Are some diets “mass murder”? (Published 15 December 2014)

Righteous Among the Nations: doctors and medical students (Published 18 December 2014)

William Fowler Felton (Published 17 December 2014)

Rodney Lloyd Herbert (Published 17 December 2014)

James Douglas Hunter (Published 17 December 2014)

Robert Miles Frankel (Published 17 December 2014)

Cyril William Holmes Havard (Published 17 December 2014)

Against the odds in Las Vegas (Published 17 December 2014)

Acute painless hepatitis in pregnancy—a cause for concern? (Published 30 December 2014)

Without frontiers (Published 18 December 2014)

Kate Granger: Quiet, determined, compassionate (Published 29 December 2014)

Managing mild, symptomatic pelvic organ prolapse (Published 22 December 2014)

Coronal proton density weighted magnetic resonance image of a 9 year old child’s left ankle and foot (Published 18 December 2014)

How might 3D printing affect clinical practice? (Published 30 December 2014)

A 3 month old boy with vomiting, intermittent crying, and lethargy (Published 31 December 2014)

My New Year’s wish is for an effective sunscreen (Published 19 December 2014)

Bias in observational study designs: prospective cohort studies (Published 19 December 2014)

MSF: how a humanitarian charity found itself leading the world’s response to Ebola (Published 23 December 2014)

Most people use adrenaline autoinjectors and asthma inhalers incorrectly, study warns (Published 18 December 2014)

Inability to balance on one leg reflects risk of brain bleed, study shows (Published 19 December 2014)

Standardised (“plain”) packaging of cigarettes regulations must be passed before the general election (Published 29 December 2014)

More than half of UK prescriptions for antipsychotics are for non-severe mental illnesses (Published 22 December 2014)

NICE guidance on place of birth falls short of neutrality (Published 31 December 2014)

What Atul Gawande teaches us about dying (Published 23 December 2014)

Cynthia Lucas (Published 19 December 2014)

Over a quarter of salmonella cases in English children are caused by pet reptiles, study finds (Published 23 December 2014)

Guinter Kahn (Published 22 December 2014)

In brief (Published 23 December 2014)

Company’s attempt to switch its patients to a new drug is foiled (Published 23 December 2014)

Approval of antiobesity drug is “major regression for patients’ safety,” says health watchdog (Published 24 December 2014)

MS patients are in sustained remission after stem cell transplantation, small study finds (Published 30 December 2014)

Death rate is lower in high risk heart patients at US teaching hospitals during cardiology conferences (Published 30 December 2014)

Margaret McCartney: Rectal feeding is torture masquerading as medicine (Published 31 December 2014)

A man with generalised lymphadenopathy (Published 12 December 2014)

Content Provider	British Medical Journal (The BMJ)
Author	Magro, Rosalie Borg, Andrew
Abstract	A 75 year old man with Paget’s disease, hypercholesterolaemia, and hypertension presented with a three year history of multiple neck lumps, which had never been investigated and had increased in size over the past two months. He felt generally well and had no history of fever or weight loss. His appetite was normal and there was no change in bowel habit. Clinical examination showed no abnormalities and he had no shortness of breath, chest pain, lower limb oedema, joint pains, or neurological symptoms. On examination, he had hepatomegaly (width of three fingers) and his cervical, axillary, and inguinal lymph nodes were enlarged, hard, and non-tender bilaterally. His blood count, renal function, and C reactive protein (<57 nmol/L; reference range 0-95) were normal. He had a raised erythrocyte sedimentation rate (102 mm in the first hour (28-32) and altered liver function tests (alkaline phosphatase 6.5 µkat/L (0.67-2.15), alanine aminotransferase 0.35 µkat/L (0.08-0.68), γ-glutamyl transferase 9.67 µkat/L (0.13-1.02), and total bilirubin 29.5 µmol/L (1.72-17.1). Proteinuria (0.25 g/L) was noted on urinalysis. Chest radiography showed mediastinal lymphadenopathy. Computed tomography of the thorax, abdomen, and pelvis showed enlarged mediastinal, axillary, and inguinal lymph nodes, which varied in size from 1 cm to 3 cm, with eggshell calcifications and an enlarged liver with hypodense texture. A lymph node biopsy was done and histological analysis performed (figure⇓). Fig 1 Section from a lymph node biopsy stained with Congo red and viewed under polarised light. Image courtesy of Ed Uthman, Houston, Texas, with permission1 ### 1. What are the causes of generalised lymphadenopathy? #### Short answer Generalised lymphadenopathy can be caused by infections (viruses, bacteria, fungi, or protozoans), cancer (including lymphoproliferative disorders), autoimmune disorders (including …
File Format	HTM / HTML
Volume Number	349
e-ISSN	17561833
DOI	10.1136/bmj.g7445
Journal	British Medical Journal (The BMJ)
Language	English
Publisher	British Medical Journal Publishing Group
Publisher Date	2014-12-12
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article

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