NDLI: Magnetic Nanoparticle Hyperthermia Cancer Therapy Temperature Distribution Modeling and Validation

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Robert, V. Stigliano Shubitidze, Fridon Hoopes, P. Jack
Copyright Year	2013
Abstract	The use of magnetic nanoparticles (mNP’s) in hyperthermia therapy for the treatment of cancer has been receiving increasing interest in the past few decades. It is known that heating cancerous tissues to temperatures above physiologically normal levels will cause cytotoxicity. In mNP hyperthermia, mNP’s are either injected intravenously or directly into the tumor site. In many tumor types the nanoparticles are invaginated into the cancer cells and aggregated into endosomes. Local temperature increases are achievable by exposing tumors containing mNP’s to an alternating magnetic field (AMF). The proximity of the mNP’s has a strong influence on their ability to generate heat due to inter-particle magnetic interaction effects [1, 2]. Taking this effect into account is important when modeling the heating characteristics of mNP’s.
Sponsorship	Nanotechnology Institute Bioengineering Division
File Format	PDF
ISBN	9780791845332
DOI	10.1115/NEMB2013-93123
Conference Proceedings	ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology
Language	English
Publisher Date	2013-02-04
Publisher Place	Boston, Massachusetts, USA
Access Restriction	Subscribed
Subject Keyword	Nanoparticles Patient treatment Temperature distribution Temperature Heat Heating Biological tissues Particulate matter Magnetic fields Modeling Cancer Tumors
Content Type	Text
Resource Type	Article

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