NDLI: Lagging Behavior in Biological Systems

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Tzou, D. Y.
Copyright Year	2009
Abstract	The lagging behavior is first exemplified by a rapidly stretched spring and a one-dimensional fin to illustrate the phase-lag concept via the thermal and mechanical properties that most engineers are familiar with. The second-order lagging model is then introduced to correlate with drug delivery in tumors and bioheat transfer that involve multiple carriers in heat/mass transport. Analytical expressions for the phase lags are derived, aiming toward revealing different physical origins for delays in different systems. For drug delivery in tumors involving nonequilibrium mass transport, the lagging behavior results from the finite time required for the rupture of liposome in releasing the antitumor drug and the finite time required for tumor cells to absorb drugs. For bioheat transfer involving nonequilibrium heat transport, on the other hand, the lagging behavior results from the finite time required for exchanging heat between tissue and blood. Pharmacodynamical and biological properties affecting the phase lags, as well as the dominating parameters over the lagging response are identified through the nondimensional analysis. Involvement of the thermal Mach number, which measures the speed of blood flow relative to the conventional thermal wave speed, is a new feature in this extension of the lagging model. The second order effects in lagging are well correlated with the number of carriers involved in nonequilibrium heat and mass transport.
Sponsorship	Nanotechnology Institute
Starting Page	523
Ending Page	535
Page Count	13
File Format	PDF
ISBN	9780791843918
DOI	10.1115/MNHMT2009-18544
e-ISBN	9780791838648
Volume Number	ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer, Volume 3
Conference Proceedings	ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer
Language	English
Publisher Date	2009-12-18
Publisher Place	Shanghai, China
Access Restriction	Subscribed
Subject Keyword	Drugs Drug delivery systems Biological tissues Rupture Anticancer drugs Mechanical properties Waves Blood Blood flow Heat Bioheat transfer Delays Engineers Springs Mach number Tumors
Content Type	Text
Resource Type	Article

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