NDLI: High Content Screening for Bio-Medical Applications

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Cathy, H. Owen Giffin, Maile Ray, K. Alley Michael, D. Chang Len, K. Higashi
Copyright Year	2006
Abstract	Near-field optics (NFO) overcomes the diffraction limit of light microscopes and permits single molecules to be imaged. Current NFO systems are designed to scan over the object being imaged and has found many applications in the physical sciences. However, there is a lack of tools that allow one to view intracellular processes, which would have many applications in the neurosciences, cancer studies and drug delivery fields. In this work, the authors have developed near-field optical probes, with nanometer apertures, that achieve much higher light throughput than conventional near-field fiber probes. The probes are designed to penetrate a living cell without destroying it. In parallel to this work, a microfluidic device has been designed and fabricated which is part of a high resolution imaging system the authors are developing. The microfluidic device or “CellTray” contains over 7000 individual wells that contain multiple cells. Together the optical probe and CellTray bring us a step closer to a lab-on-a-chip device for biomedical research.
Sponsorship	Nanotechnology Institute
Starting Page	303
Ending Page	307
Page Count	5
File Format	PDF
ISBN	0791847616
DOI	10.1115/MN2006-17035
e-ISBN	0791837858
Volume Number	Multifunctional Nanocomposites
Conference Proceedings	ASME 2006 Multifunctional Nanocomposites International Conference
Language	English
Publisher Date	2006-09-20
Publisher Place	Honolulu, Hawaii, USA
Access Restriction	Subscribed
Subject Keyword	Drug delivery systems Optics Biological cells Fibers Biomedicine Diffraction Imaging Resolution (optics) Optical microscopes Wells Probes Microfluidics Cancer
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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