NDLI: Tissue- and Cell-Level Stress Distributions of the Heart Valve Tissue During Diastole

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Huang, Siyao Huang, Hsiao-Ying Shadow
Copyright Year	2013
Abstract	Heart valves are inhomogeneous microstructure with nonlinear anisotropic properties and constantly experience different stress states during cardiac cycles. However, how tissue-level mechanical forces can translate into altered cellular stress states remains unclear, and associated biomechanical regulation in the tissue has not been fully understood. In the current study, we use an image-based finite element method to investigate factors contributing the stress distributions at both tissue- and cell-levels inside the healthy heart valve tissues. Effects of tissue microstructure, inhomogeneity, and anisotropic material property at different diastole states are discussed to provide a better understanding of structure-mechanics-property interactions, which alters tissue-to-cell stress transfer mechanisms in heart valve tissue. To the best of the authors’ knowledge, this is the first study reporting on the evolution of stress fields at both the tissue- and cellular-levels in valvular tissue, and thus contributes toward refining our collective understanding of valvular tissue micromechanics while providing a computational tool enabling further study of valvular cell-tissue interactions.
File Format	PDF
ISBN	9780791856383
DOI	10.1115/IMECE2013-63229
Volume Number	Volume 9: Mechanics of Solids, Structures and Fluids
Conference Proceedings	ASME 2013 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2013-11-15
Publisher Place	San Diego, California, USA
Access Restriction	Subscribed
Subject Keyword	Biomechanics Cardiac cycle Biological tissues Anisotropy Materials properties Valves Finite element methods Stress Micromechanics (engineering)
Content Type	Text
Resource Type	Article

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