NDLI: Modeling of Transient Tissue Temperatures and Biotransport of Vasodilators During Localized Heating

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Chen, Cuiye Robert, B. Roemer
Copyright Year	2003
Abstract	Thermally induced large blood flow increases have been extensively observed in muscle. However, no one has attempted to study the physiological mechanisms that under these phenomena. If the mechanisms are fully understood, it may be possible to noninvasively, thermally control blood flow, thus controlling tissue temperature, during hyperthermia treatments. The present study applies a compartmental model of the pharmacokinetics/dynamics coupled with a one-dimensional Pennes bio-heat-transfer equation to study the local thermoregulation in tissue subjected to heating. Temperature responses to different applied power levels have been simulated. The simulations are seen to generate similar temperature profiles to those observed in the previous in vivo experiments. This implies that the coupled pharmacokinetic/dynamic and 1D energy balance models developed here capture the essence of the links between tissue temperature and blood flow oscillations and the activities of the vasoactive substances. Thus, it appears that such pharmacokinetic/dynamic models can provide a fundamental basis for coupling the tissue temperature distributions to blood flow oscillations—as opposed to using the ad hoc time delays used in the original investigations. Results from this study provide a promising, physiological basis for coupling blood flow increase with localized heating, which can be used as a guideline for the design of physiological experiments to identify the key vasoactive agents present during heating. In addition, once the key vasodilators are identified and the corresponding biochemical pathways are fully understood, research can then proceed to find a way to thermally control blood flow for the purpose of enhancing the efficacy of noninvasive thermal therapies.
Sponsorship	Heat Transfer Division
Starting Page	431
Ending Page	438
Page Count	8
File Format	PDF
ISBN	0791837181
DOI	10.1115/IMECE2003-42044
Volume Number	Heat Transfer, Volume 4
Conference Proceedings	ASME 2003 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2003-11-15
Publisher Place	Washington, DC, USA
Access Restriction	Subscribed
Subject Keyword	Temperature distribution Temperature Biological tissues Oscillations Temperature profiles Modeling Transients (dynamics) Blood flow Design Energy budget (physics) Patient treatment Simulation Biotransport Heating Dynamics (mechanics) Bioheat transfer Dynamic models Physiology Muscle Delays Engineering simulation Pharmacokinetics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Simulation of Empirical Correlations Between Temperatures and Blood Perfusion During Heating Using a Temperature-Dependent Blood Perfusion Model

Numerical Simulation of Freezing of Biological Tissue

Analysis of Temperature Response in Biological Tissue With Sinusoidal Temperature Oscillation on the Skin

Transient Temperature Profiles in Tissues With Nonuniform Blood Flow Distributions

Reduced Order Modeling and Compression of Data Produced by Simulations of Transient and Periodic Heat Transfer Processes

Simulation of Focused Radiation Propagation and Transient Heat Transfer in Turbid Tissues

Bioheat Transfer in a Branching Countercurrent Network During Hyperthermia

Inverse Heat Transfer Analysis of Micro Heater Strength and Locations for Hyperthermia Treatment of Brain Tumors

Analytical Temperature Distribution in a Multi-Layer Tissue Structure in the Presence of a Tumor

Modeling of Transient Tissue Temperatures and Biotransport of Vasodilators During Localized Heating

Similar Documents

Simulation of Empirical Correlations Between Temperatures and Blood Perfusion During Heating Using a Temperature-Dependent Blood Perfusion Model

Numerical Simulation of Freezing of Biological Tissue

Analysis of Temperature Response in Biological Tissue With Sinusoidal Temperature Oscillation on the Skin

Transient Temperature Profiles in Tissues With Nonuniform Blood Flow Distributions

Reduced Order Modeling and Compression of Data Produced by Simulations of Transient and Periodic Heat Transfer Processes

Simulation of Focused Radiation Propagation and Transient Heat Transfer in Turbid Tissues

Bioheat Transfer in a Branching Countercurrent Network During Hyperthermia

Inverse Heat Transfer Analysis of Micro Heater Strength and Locations for Hyperthermia Treatment of Brain Tumors

Analytical Temperature Distribution in a Multi-Layer Tissue Structure in the Presence of a Tumor

Modeling of Transient Tissue Temperatures and Biotransport of Vasodilators During Localized Heating