NDLI: Application of Self-Control in Droplet-Based Microfluidics

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Kielpinski, Mark Malsch, Danie´ll Gleichmann, Nils Mayer, Gu¨nter Henkel, Thomas
Copyright Year	2008
Abstract	Droplet-based microfluidics provide a powerful platform for high-throughput operations applied in micro analytics, micro reaction technology and live sciences. Todays research interests focus on the development of highly integrated fluidic networks for sample processing according to a microchemical or microanalytical protocol. Normally, fluidic networks with integrated fluidic loops and bypasses are very complicated systems that require a huge effort for external control and integration of actor components. In contrast, in droplet-based microfluidics interface generated forces can be used to temporarily seal bypasses or to generate well defined pressure gradients at strictures. This potential can be used to implement self-control and self-synchronization at functional nodes in order to minimize the effort for external control and actors integration. Here we report on progress in development of functional nodes for self-synchronized 1:1 coalescence of two independently generated droplet sequences at a Y-shaped junction and on approaches for droplet aliquotation at a Y-shaped bifurcation. The droplet connector automatically balances the time delay between two droplets arriving at the junction. On this account, strictures are integrated into the Y-junction and an additional bypass connects the arriving channels. The first arriving droplet stops at the stricture until its fusion partner arrives. The droplet splitter performs an 1:1 aliqoutation of all elements of a droplet sequence. The main challenges are the balancing of pressure differences at the outlets and the correct aliquotation of droplets independent of their volume at a wide range of flow rates. The splitter design is based on the rule that forces required for splitting are always lower than the forces required for complete droplet inflow into only one of the outlet channels without splitting.
Sponsorship	Nanotechnology Institute
Starting Page	1565
Ending Page	1570
Page Count	6
File Format	PDF
ISBN	0791848345
DOI	10.1115/ICNMM2008-62325
e-ISBN	0791838269
Conference Proceedings	ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels
Language	English
Publisher Date	2008-06-23
Publisher Place	Darmstadt, Germany
Access Restriction	Subscribed
Subject Keyword	Design Drops Bifurcation Delays Pressure gradient Inflow Synchronization Junctions Flow (dynamics) Pressure Microfluidics
Content Type	Text
Resource Type	Article

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