NDLI: An In Silico Investigation of a Lobe-Specific Targeted Pulmonary Drug Delivery Method

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An In Silico Investigation of a Lobe-Specific Targeted Pulmonary Drug Delivery Method

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Feng, Yu Chen, Xiaole Yang, Mingshi
Copyright Year	2018
Abstract	Nowadays, “personalized medicine” is starting to replace the current “one size fits all” approach. The goal is to have the right drug with the right dose for the right patient at the right time and location. Indeed, conventional pulmonary drug delivery devices still have poor efficiencies (<25%) for delivering drugs to the lung tumor sites. Major portions of the aggressive medicine deposit on healthy tissue, which causes severe side effects and induces extra health care expenses. Therefore, a new targeted pulmonary drug delivery method is proposed and evaluated using the Computational Fluid-Particle Dynamics (CFPD) method to achieve the lobe-specific delivery. By controlling the release position and velocity of the drug particles at the mouth inlet, drug deposition efficiency (DE) in a designated lobe can be increased up to 90%. Intersubject variability has also been investigated using the noninvasive in silico tool. Results indicate that the glottis constriction ratio is a key factor to influence the effectiveness of the purposed targeted drug delivery method. Although lobe-specific pulmonary drug delivery can be realized, the actuation flow rate must be lower than 2 L/min, and the glottis constriction ratio has a significant impact on the effectiveness of the targeting method. Also, a design idea using e-cigarette as the prototype is proposed as the next-generation inhaler to accommodate the operational flexibility restrictions.
File Format	PDF
ISBN	9780791840788
DOI	10.1115/DMD2018-6928
Conference Proceedings	2018 Design of Medical Devices Conference
Language	English
Publisher Date	2018-04-09
Publisher Place	Minneapolis, Minnesota, USA
Access Restriction	Open
Subject Keyword	Drugs Health care Drug delivery systems Biological tissues Lung Flow (dynamics) Design Fluids Biomedicine Dynamics (mechanics) Particulate matter Engineering prototypes Tumors
Content Type	Text
Resource Type	Article

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