NDLI: Automated Indirect Optical Micromanipulation of Biological Cells Using Indirect Pushing for Minimizing Photo-Damage

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Thakur, Atul Chowdhury, Sagar Svec, Petr Wang, Chenlu Losert, Wolfgang Satyandra, K. Gupta
Copyright Year	2012
Abstract	Precise micromanipulation of cells or other living systems is allowing for cell transport, sorting, characterization of mechanical properties, cell-cell interaction, migration studies, etc. In this paper, we report an automated indirect pushing-based approach for micromanipulation of cells using dielectric silica beads. In this approach, an optically actuated dielectric silica bead pushes on other bead that in turn pushes the cell, thereby minimizing photo-damage. We have defined three parametrized atomic maneuvers namely, push, align, and go behind the intermediate bead and used them to compose a feedback plan for in-direct pushing. We have developed a simplified dynamics model, which is used in the simulation of operations involving pushing of cells using optically trapped beads. We also present an optimization-based approach for automated tuning of maneuver parameters for different turning angles and measurement noise to increase the robustness of the developed feedback planner. Finally, we have tested the developed planner on a physical setup and obtained experimental results.
Sponsorship	Design Engineering Division Computers and Information in Engineering Division
Starting Page	221
Ending Page	229
Page Count	9
File Format	PDF
ISBN	9780791845042
DOI	10.1115/DETC2012-71214
Volume Number	Volume 5: 6th International Conference on Micro- and Nanosystems; 17th Design for Manufacturing and the Life Cycle Conference
Conference Proceedings	ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
Language	English
Publisher Date	2012-08-12
Publisher Place	Chicago, Illinois, USA
Access Restriction	Subscribed
Subject Keyword	Noise (sound) Simulation Feedback Dynamics (mechanics) Mechanical properties Robustness Micromanipulation Damage Biological cells Optimization Turning angles
Content Type	Text
Resource Type	Article

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