NDLI: Numerical Modeling of Plate Electroporation Thermal Dose Assessment

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Becker, S. M. Kuznetsov, A. V.
Copyright Year	2006
Abstract	Electroporation is an approach used to enhance the transport of large molecules to the cell cytosol in which a targeted tissue region is exposed to a series of electric pulses. The cell membrane, which normally acts as a barrier to large molecule transport into the cell interior, is temporarily destabilized due to the development of pores in the cell membrane. Consequently, agents that are ordinarily unable enter the cell are able to pass through the cell membrane. Of possible concern when exposing biological tissue to an electric field is thermal tissue damage associated with joule heating. This paper explores the thermal effects of various geometric, biological, and electroporation pulse parameters including the blood vessel presence and size, plate electrode configuration, and pulse duration and frequency. A three-dimensional transient finite volume model of in vivo parallel plate electroporation of liver tissue is used to develop a better understanding of the underlying relationships between the physical parameters involved with tissue electroporation and resulting thermal damage potential.
Starting Page	76
Ending Page	84
Page Count	9
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	128
Issue Number	1
DOI	10.1115/1.2132375
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2005-08-18
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biological tissues Blood Blood vessels Computer simulation Cycles Electric fields Electrodes Electroporation Heat Heating Temperature Temperature profiles Vessels
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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