NDLI: The Eyes Absent Family of Phosphotyrosine Phosphatases: Properties and Roles in Developmental Regulation of Transcription

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Volume 85

Volume 84

Molecular Mechanisms of Antibody Somatic Hypermutation

Structure and Mechanism of Helicases and Nucleic Acid Translocases

The Nonsense-Mediated Decay RNA Surveillance Pathway

Functions of Site-Specific Histone Acetylation and Deacetylation

The tmRNA System for Translational Surveillance and Ribosome Rescue

Membrane Protein Structure: Prediction versus Reality

Structure and Function of Toll Receptors and Their Ligands

The Role of Mass Spectrometry in Structure Elucidation of Dynamic Protein Complexes

Structure and Mechanism of the 6-Deoxyerythronolide B Synthase

The Biochemistry of Methane Oxidation

Anthrax Toxin: Receptor Binding, Internalization, Pore Formation, and Translocation

Synapses: Sites of Cell Recognition, Adhesion, and Functional Specification

Lipid A Modification Systems in Gram-Negative Bacteria

Chemical Evolution as a Tool for Molecular Discovery

Molecular Mechanisms of Magnetosome Formation

Modulation of the Ryanodine Receptor and Intracellular Calcium

TRP Channels

Studying Individual Events in Biology

Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk

Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

The Eyes Absent Family of Phosphotyrosine Phosphatases: Properties and Roles in Developmental Regulation of Transcription

Assembly Dynamics of the Bacterial MinCDE System and Spatial Regulation of the Z Ring

Structures and Functions of Yeast Kinetochore Complexes

Mechanism and Function of Formins in the Control of Actin Assembly

Unsolved Mysteries in Membrane Traffic

Structural Biology of Nucleocytoplasmic Transport

The Magic Garden

DNA Replication and Transcription in Mammalian Mitochondria

Mitochondrial-Nuclear Communications

Translocation of Proteins into Mitochondria

The Machines that Divide and Fuse Mitochondria

Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View

The Eyes Absent Family of Phosphotyrosine Phosphatases: Properties and Roles in Developmental Regulation of Transcription

Content Provider	Annual Reviews
Author	Jemc, Jennifer Rebay, Ilaria
Description	Author Affiliation: •Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142(Jennifer Jemc).•Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois 60637 (Ilaria Rebay).
Abstract	Integration of multiple signaling pathways at the level of their transcriptional effectors provides an important strategy for fine-tuning gene expression and ensuring a proper program of development. Posttranslational modifications, such as phosphorylation, play important roles in modulating transcription factor activity. The discovery that the transcription factor Eyes absent (Eya) possesses protein phosphatase activity provides an interesting new paradigm. Eya may regulate the phosphorylation state of either itself or its transcriptional cofactors, thereby directly affecting transcriptional output. The identification of a growing number of transcription factors with enzymic activity suggests that such dual-function proteins exert greater control of signaling events than previously imagined. Given the conservation of both its phosphatase and transcription factor activity across mammalian species, Eya provides an excellent model for studying how a single protein integrates these two functions under the influence of multiple signaling pathways to promote development.
Starting Page	513
Ending Page	538
Page Count	26
File Format	HTM / HTML PDF
ISSN	00664154
e-ISSN	15454509
DOI	10.1146/annurev.biochem.76.052705.164916
Volume Number	76
Language	English
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Drosophila eye HAD phosphatase Retinal determination gene network Signal transduction Transcription factor
Content Type	Text
Resource Type	Article
Subject	Biochemistry

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The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases

Regulation of Yin Yang 1 by Tyrosine Phosphorylation

Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network

Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent

Differential expression of retinal determination genes in the principal and secondary eyes of Cupiennius salei Keyserling (1877)

Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund

The Retinal Determination Gene eyes absent Is Regulated by the EGF Receptor Pathway Throughout Development in Drosophila

Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila

Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction.

The Eyes Absent Family of Phosphotyrosine Phosphatases: Properties and Roles in Developmental Regulation of Transcription

Similar Documents

The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases

Regulation of Yin Yang 1 by Tyrosine Phosphorylation

Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network

Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent

Differential expression of retinal determination genes in the principal and secondary eyes of Cupiennius salei Keyserling (1877)

Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund

The Retinal Determination Gene eyes absent Is Regulated by the EGF Receptor Pathway Throughout Development in Drosophila

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The Eyes Absent Family of Phosphotyrosine Phosphatases: Properties and Roles in Developmental Regulation of Transcription