NDLI: Copper Metallochaperones

Please wait, while we are loading the content...

Volume 85

Volume 84

From Virus Structure to Chromatin: X-ray Diffraction to Three-Dimensional Electron Microscopy

Genomic Screening with RNAi: Results and Challenges

Nanomaterials Based on DNA

Eukaryotic Chromosome DNA Replication: Where, When, and How?

Regulators of the Cohesin Network

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

Origins of Specificity in Protein-DNA Recognition

Transcript Elongation by RNA Polymerase II

Biochemical Principles of Small RNA Pathways

Functions and Regulation of RNA Editing by ADAR Deaminases

Regulation of mRNA Translation and Stability by microRNAs

Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome

Adding New Chemistries to the Genetic Code

Bacterial Nitric Oxide Synthases

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

Hydrogenases from Methanogenic Archaea, Nickel, a Novel Cofactor, and H2 Storage

Copper Metallochaperones

High-Throughput Metabolic Engineering: Advances in Small-Molecule Screening and Selection

Botulinum Neurotoxin: A Marvel of Protein Design

Chemical Approaches to Glycobiology

Cellulosomes: Highly Efficient Nanomachines Designed to Deconstruct Plant Cell Wall Complex Carbohydrates

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Physical Mechanisms of Signal Integration by WASP Family Proteins

Amphipols, Nanodiscs, and Fluorinated Surfactants: Three Nonconventional Approaches to Studying Membrane Proteins in Aqueous Solutions

Protein Sorting Receptors in the Early Secretory Pathway

Virus Entry by Endocytosis

Volume 78

Volume 77

Volume 76

Copper Metallochaperones

Content Provider	Annual Reviews
Author	Robinson, Nigel J. Winge, Dennis R.
Description	Author Affiliation: •Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, NE2 4HH, United Kingdom (Nigel J. Robinson).•University of Utah Health Sciences Center, Salt Lake City, Utah 84132 (Dennis R. Winge).
Abstract	The current state of knowledge on how copper metallochaperones support the maturation of cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and intramembrane CuB sites of cytochrome oxidase, within the trans-Golgi network to supply secreted cuproproteins and within the cytosol to supply superoxide dismutase 1 (Sod1). Subpopulations of copper-zinc superoxide dismutase also localize to mitochondria, the secretory system, the nucleus and, in plants, the chloroplast, which also requires copper for plastocyanin. Prokaryotic cuproproteins are found in the cell membrane and in the periplasm of gram-negative bacteria. Cu(I) and Cu(II) form tight complexes with organic molecules and drive redox chemistry, which unrestrained would be destructive. Copper metallochaperones assist copper in reaching vital destinations without inflicting damage or becoming trapped in adventitious binding sites. Copper ions are specifically released from copper metallochaperones upon contact with their cognate cuproproteins and metal transfer is thought to proceed by ligand substitution.
Starting Page	537
Ending Page	562
Page Count	26
File Format	HTM / HTML PDF
ISSN	00664154
e-ISSN	15454509
DOI	10.1146/annurev-biochem-030409-143539
Volume Number	79
Language	English
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	P1-type ATPase Cytochrome oxidase Cox17 CopZ Atx1 Ccs1
Content Type	Text
Resource Type	Article
Subject	Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Atx1-like chaperones and their cognate P-type ATPases: copper-binding and transfer

Interaction between cyanobacterial copper chaperone Atx1 and zinc homeostasis

Crystal structure of yeast Sco1

The CopA2-Type P1B-Type ATPase CcoI Serves as Central Hub for cbb3-Type Cytochrome Oxidase Biogenesis

Interplay between glutathione, Atx1 and copper: X-ray absorption spectroscopy determination of Cu(I) environment in an Atx1 dimer

Knock-down of the COX3 and COX17 gene expression of cytochrome c oxidase in the unicellular green alga Chlamydomonas reinhardtii

NMR structural analysis of the soluble domain of ZiaA-ATPase and the basis of selective interactions with copper metallochaperone Atx1

Interplay between glutathione, Atx1 and copper. 1. Copper(I) glutathionate induced dimerization of Atx1

Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase

Copper Metallochaperones

Similar Documents

Atx1-like chaperones and their cognate P-type ATPases: copper-binding and transfer

Interaction between cyanobacterial copper chaperone Atx1 and zinc homeostasis

Crystal structure of yeast Sco1

The CopA2-Type P1B-Type ATPase CcoI Serves as Central Hub for cbb3-Type Cytochrome Oxidase Biogenesis

Interplay between glutathione, Atx1 and copper: X-ray absorption spectroscopy determination of Cu(I) environment in an Atx1 dimer

Knock-down of the COX3 and COX17 gene expression of cytochrome c oxidase in the unicellular green alga Chlamydomonas reinhardtii

NMR structural analysis of the soluble domain of ZiaA-ATPase and the basis of selective interactions with copper metallochaperone Atx1

Interplay between glutathione, Atx1 and copper. 1. Copper(I) glutathionate induced dimerization of Atx1

Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase

Copper Metallochaperones