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| Content Provider | African Journals Online (AJOL) |
|---|---|
| Author | Jia Tang Yan Huang Hao Wen Ling-fang Xia Shan-hui Liang |
| Abstract | Purpose: To investigate the anti-tumor effects of polysaccharides from Curculigo orchioides (PDC) on cervical cancer and the possible mechanisms involved.Methods: A Box–Behnken design (BBD) was employed to optimize extraction conditions for PDC. The anti-tumor effect of PDC on cervical cancer was investigated in vivo in mice injected with Hela cells. The parameters measured were tumor volume and weight. In vitro anti-tumor effects of PDC were assessed by measuring expressions of caspase-3, caspase-9 and P53 proteins in Hela cells via ELISA assay. Thymus and spleen indices were calculated for assessment of PDC effect on immune function.Results: The optimum extraction conditions predicted by the response surface methodology (RSM) were: extraction time = 1.58 h, ratio-of-water-to-sample = 30.05 mL/g and extraction number = 1.95. PDC showed significant anti-tumor effect on cervical cancer in mice. It significantly increased thymus and spleen indices in mice; and significantly up-regulated expressions of caspase-3, caspase-9 and P53 proteins in HeLa cells.Conclusion: PDC has significant anti-tumor effect on cervical cancer in vivo and in vitro, most probably through mechanisms involving enhancement on immune function and induction of apoptosis. |
| Ending Page | 1737 |
| Starting Page | 1731 |
| File Format | |
| ISSN | 15965996 |
| e-ISSN | 15969827 |
| DOI | 10.4314/tjpr.v15i8.19 |
| Journal | Tropical Journal of Pharmaceutical Research |
| Issue Number | 8 |
| Volume Number | 15 |
| Language | English |
| Publisher Date | 2016-09-05 |
| Access Restriction | Open |
| Subject Keyword | Health Curculigo orchioides Polysaccharides Cervical cancer HeLa cells Apoptosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmacology (medical) Pharmaceutical Science |
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