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Time to Reactivation of Latent Tuberculosis Infection Varies by Lineage

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Time to Reactivation of Latent Tuberculosis Infection Varies by Lineage

Content Provider	ACM Digital Library
Author	Thieme, Nick Bennett, Kristin P.
Abstract	Infection by Mycobacterium tuberculosis complex (MTB) produces either active tuberculosis (TB) disease or latent infections without symptoms with about a 10% lifetime risk of developing disease. We hypothesize that MTB lineages may have different latent reactivation phenotypes, and that these different phenotypes would be reflected in different disease dynamics in foreign-born TB patients in New York City (NY). We define the time to disease (TTD) as the length of time between a subject's arrival in the US and development of active disease. We study statistical differences in TTD distributions for the four most prevalent MTB lineages. By studying foreign-born patients with unique genotype MTB, TTD can serve as a proxy for time to latent reactivation. We observe significant differences between the TTD distributions among the 4 lineages using the Anderson-Darling (AD) test. Deeper understanding of latent reactivation can support TB control efforts and aid development of new tuberculosis drugs targeted toward latent TB.
Starting Page	493
Ending Page	494
Page Count	2
File Format	PDF
ISBN	9781450342254
DOI	10.1145/2975167.2985649
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2016-10-02
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Tuberculosis Molecular epidemiology Bioinformatics
Content Type	Text
Resource Type	Article

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