NDLI: Compuational analyses of developmental cis-regualtory control systems (invited presentation)

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Compuational analyses of developmental cis-regualtory control systems (invited presentation)

Content Provider	ACM Digital Library
Author	Davidson, Eric
Abstract	Developmental processes are hardwired in the genomic DNA of each animal species. The DNA sequences that specify the architecture of developmental control networks are the cis-regulatory elements that individually determine the state of activity of each of the many genes required to generate a developmental event. These elements each mediate many interactions with transcription factors, which are selected with high specificity according to the target binding sites in each cis-regulatory element. Cis-regulatory elements can be thought of as analog information processing devices. This concept is illustrated by an experimental and computational analysis of a cis-regulatory system from the developmentally regulated Endo 16 gene of the sea urchin embryo. Large-scale developmental events require mobilization of batteries of downstream genes, and are instituted by signal inputs to regulatory genes encoding transcription factors. Functional linkages between genes determine which signals affect which regulatory genes, in space and time, and which gene batteries will be involved. Thus both inter cis-regulatory networks and intra cis-regulatory systems are specified by arrays of genomic target site sequences. A model of an intergenic network of this kind that controls endomesoderm specification in sea urchin embryos has been constructed on the basis of experimental information. This model consists of a set of predicted inputs and outputs to a minimal group of regulatory genes encoding endodermal and mesodermal transcription factors, and components of signaling systems. The predictions of the model are experimentally testable, and indeed some such model is a clear necessity for productive experimental analysis.
File Format	PDF
ISBN	1581131860
DOI	10.1145/332306.332923
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2000-04-08
Publisher Place	New York
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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