NDLI: Two-phase prediction of protein functions from biological literature based on Gini-Index

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Two-phase prediction of protein functions from biological literature based on Gini-Index

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Two-phase prediction of protein functions from biological literature based on Gini-Index

Content Provider	ACM Digital Library
Author	Park, Heum Kwon, Hyuk-Chul Park, DaeWon
Abstract	This paper presents a two-phase prediction model for proteins and protein functions from biological literature based on Gini Index algorithm. As the volume and diversity of biological resources grows, computational protein function prediction become much more important. In this paper, we considered automatic annotation of the Gene Ontology (GO) by computational function prediction approaches entailing feature selection method based on Gini Index and protein function prediction model. Gini-Index has been used as a split measure for choosing the most appropriate splitting attribute in decision tree. Recently, the Gini-Index algorithm for feature selection in text categorization was introduced and proved to be good performances. Thus, we present a novel model to predict both multi-label proteins from PubMed literatures and their functions from protein-function of GO Annotation. First, we introduce a feature selection algorithm with Gini-Index expressions to predict proteins from PubMed and obtain proteintext subsets. Second, we propose a novel two-phase prediction method for proteins and their protein functions with those subsets. As experimental results, we evaluated the results of prediction for the proteins and their functions using the proposed methods. We have good performances notably overall for both of prediction of proteins and protein function from the biological literatures.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISBN	9781450305716
DOI	10.1145/1968613.1968687
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2011-02-21
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Feature selection Go annotation Gini-index Protein function prediction
Content Type	Text
Resource Type	Article

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