NDLI: Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process

Please wait, while we are loading the content...

A robust image segmentation method using hierarchical color clustering

Energy optimization in wireless body area network based on ZigBee

Intelligent model system for tourism flow prediction: a study of Xi'an Museum

Garment fold enhancement simulation method based on energy field

A hybrid collaborative filtering recommendation algorithm

Multiple attribute decision making with completely unknown weights based on cumulative prospect theory and grey system theory

The adaption of the Cuckoo search algorithm applied in the LEACH-C protocol

Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process

A following behavior detecting method for drive assistance

Battle simulation of network information system-of-systems based on multi-agent

Improved face recognition result reranking based on shape contexts

Price decision-making models in closed-loop supply chain based on government subsidies: a new replacement policy of household appliances in China

Individualized learning through MOOC: online automatic test system based on genetic algorithm

An algorithm for evaluating the influence of micro-blog users

Pseudo-samples generation in Gaussian mixture distribution for software defect prediction

Software defect prediction based on manifold learning in subspace selection

SwingPong: analysis and suggestion based on motion data from mobile sensors for table tennis strokes using decision tree

The study and implementation of VoIP intelligent voice communication system based on SIP protocol

Research on phase compensating factor of chirp scaling algorithm in multiple-receiver synthetic aperture sonar

Benchmark of a large scale database for facial beauty prediction

Analysis of planar mobile distribution and interference evaluation in wireless ad-hoc networks

Compressive sensing for space image compressing

Security problems analysis and solving policy design for mobile agents running platform

Traffic features extraction and clustering analysis for abnormal behavior detection

Simulation research on PID_MRAC control of 6-DOF platform servo system

Comparative study of load balancing routing algorithms in hybrid networks

The evaluation and improvement of traffic rule: based on intelligent information processing

An extended fine-grained conflict detection method for shared-state scheduling in large scale cluster

Influence of oil groove geometry on the lubrication characteristic of planet gear thrust washer

Research on risk assessment of CTCS based on fuzzy reasoning and analytic hierarchy process

Technology research of ultra-tightly integration about INS aided tracking loop based on EKF

Independent components for EEG signal classification

A VEIS computer virus propagation model based on partly immunization

An effective joint model for chinese word segmentation and POS tagging

An empirical study on the collaboration of scholars in graduate education: based on the social network analysis

Research on improved information fusion of accelerometers based on MEMD technology

Data caching policies for device to device within cellular networks

A novel scheme for D2D resource allocation based on users' data rate requirements

CSMA/CA through put analysis in hybrid CSMA/CA and TDMA networks

Research on sales forecasting based on ARIMA and BP neural network combined model

Noise reduction of hyperspectral imagery based on hypergraph laplacian regularized low-rank representation

Hyperspectral image tensor feature extraction based on fusion of multiple spectral-spatial features

An over-sampling method based on probability density estimation for imbalanced datasets classification

Feature data factorization and its application

A new method of deep synergetic neural network for face recognition

Robust two-step image restoration with adaptive regularization parameter

Comprehensive comparison study on different ICA/BSS methods in IPPG techniques for obtaining high-quality BVP signal

Channel refined directional color filter array interpolation

Effect of variation factors on the processing time of the face recognition algorithms in video sequence

ANN: a heuristic search algorithm based on artificial neural networks

SAR automatic target recognition based on K-means and data augmentation

An image processing system for evaluation of aerial application quality

Personalized sensitive attribute anonymity based on P - sensitive k anonymity

Load pattern analysis of key accounts based on two-step clustering

Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process

Content Provider	ACM Digital Library
Author	Cui, Xianglong Wang, Xin Qiao, Yanjiang Shi, Xinyuan Xu, Bing Sun, Fei
Abstract	This paper presented a combinatorial application of quality by design (QbD) and quality risk management (QRM) tools with the goal of managing process risk and achieving high level of quality control during the development of the high shear wet granulation (HSWG) process. The microcrystalline cellulose and deionized water system was taken as the research object. By defining the critical quality attributes (CQAs) for the granules product, the probabilistic failure modes effects analysis (PFMEA) was innovatively used to assess the potential risks associated with the HSWG process on product quality and prioritize the potential critical process parameters (pCPPs) that must be controlled. Then, the Plackett-Burman design was used to screen critical process parameters (CPPs) from pCPPs. As a result, three operating parameters, i.e. the liquid to solid ratio, the wet massing time and the wet mixing impeller speed were identified as CPPs, and their quantitative relationship with CQAs were further investigated by using the Box-Behnken design. The design space which remained safely away from the edge of failure was built and validated. Retrospective risk analysis results demonstrated that the established process control strategies were efficient to ensure the granules consistently meet the specifications.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISBN	9781450347990
DOI	10.1145/3028842.3028850
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2016-12-23
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Design space High shear wet granulation Quality by design Control strategy Risk analysis Multivariate data analysis
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to Prepare a Combination Drug Using Integrated Quality by Design

Development of critical quality attributes control strategies in a continuous high shear wet granulation process

Improved Understanding of the High Shear Wet Granulation Process under the Paradigm of Quality by Design Using Salvia miltiorrhiza Granules

De-risking Scale-up of a High Shear Wet Granulation Process Using Latent Variable Modeling and Near-Infrared Spectroscopy

Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation.

Real-Time Monitoring of Critical Quality Attributes during High-Shear Wet Granulation Process by Near-Infrared Spectroscopy Effect of Water Addition and Stirring Speed on Pharmaceutical Properties of the Granules

Processing a detergent powder formulation: Direct compression, and high shear wet granulation followed by compression

End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process.

Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation

Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process

Similar Documents

Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to Prepare a Combination Drug Using Integrated Quality by Design

Development of critical quality attributes control strategies in a continuous high shear wet granulation process

Improved Understanding of the High Shear Wet Granulation Process under the Paradigm of Quality by Design Using Salvia miltiorrhiza Granules

De-risking Scale-up of a High Shear Wet Granulation Process Using Latent Variable Modeling and Near-Infrared Spectroscopy

Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation.

Real-Time Monitoring of Critical Quality Attributes during High-Shear Wet Granulation Process by Near-Infrared Spectroscopy Effect of Water Addition and Stirring Speed on Pharmaceutical Properties of the Granules

Processing a detergent powder formulation: Direct compression, and high shear wet granulation followed by compression

End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process.

Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation

Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process