NDLI: An Autonomous and Adaptive Bacteria-based Drug Delivery System

Content Provider	ACM Digital Library
Author	Lo, Chieh Bhardwaj, Kartikeya Marculescu, Radu
Abstract	Traditional drug delivery systems are often inefficient and imprecise as they mainly rely on diffusion processes. For example, the blood circulation system is often used to transport and deliver drugs throughout the body; due to the randomness involved in molecular diffusion, this approach may cause inefficient delivery of drugs. To deal with this problem, we propose an autonomous and adaptive bacteria-based drug delivery system that integrates bacterial chemotaxis and quorum sensing to deliver drugs efficiently and precisely. More specifically, we design a synthetic AND gate that enables bacteria to detect the molecules produced by a particular type of tumor and release the appropriate drugs in a coordinated manner; the system can also dynamically adjust the amount of drugs released based on tumor size and activity. We envision that such a system can be used for cell-based therapeutics while preventing drug overuse and multidrug resistance.
Starting Page	1
Ending Page	6
Page Count	6
File Format	PDF
ISBN	9781450340618
DOI	10.1145/2967446.2967458
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2016-09-28
Publisher Place	New York
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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An Autonomous and Adaptive Bacteria-based Drug Delivery System