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| Content Provider | ACM Digital Library |
|---|---|
| Author | Priemer, Roland McCormick, Bruce H. |
| Abstract | A television ophthalmoscope (TVO) developed at the University of Illinois at Chicago combines low-light-level television camera and digital image processor to acquire and analyze images of the retina and chorold, one of the few areas of the body where the circulatory system can be observed in detail without surgery. So Far the TVO has been used in two-wavelength oxlmetry to measure oxygen saturation in the blood—a measure useful in diagnosing and treating diabetes, with potential for better management of sickle-cell anemia, hypertension and other systemic diseases. The TVO image processor also analyzes multispectral reflectance images which have been used, for example, to calculate and display difference images of visual pigment density, related to night blindness and other inherited ele disorders. In addition, the use of the TVO in quantitative angiography has contributed to understanding of the dynamics of retinal/choroidal blood flow. Experimental studies are presented that demonstrate two complementary techniques for the extraction of hemodynamic parameters from TVO-derived anglographic data. In particular both the frequency domain technique and the time domain technique presented are capable of obtaining retinal circulation time (RCT) estimates from nonuniformly sampled and noisy dye dilution curves. Both methods use identical input (artery dye dilution curve) and response (vein dye dilution curve). The frequency domain technique uses this information for obtaining transfer function estimates of the retinal capillary bed. These estimates are then used to obtain minimum mean square error values of parameters in a model of the capillary bed. The model was chosen so as to account for both the tracer transit time, which is the time the response is delayed relative to the input, and tracer dispersion, which is the extent to which the response pulse is spread out relative to the input pulse. This spreading effect is determined by the variation in capillary lengths within a capillary bed and by various types of mixing. |
| Starting Page | 686 |
| Ending Page | 697 |
| Page Count | 12 |
| File Format | |
| Language | English |
| Publisher | Association for Computing Machinery (ACM) |
| Publisher Date | 1984-01-01 |
| Access Restriction | Subscribed |
| Content Type | Text |
| Resource Type | Article |
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