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  1. Proceedings of the Symposium on Modeling and Simulation in Medicine (MSM '15)
  2. Rule-based modelling and simulation of drug-administration policies
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Rule-based modelling and simulation of drug-administration policies

Content Provider ACM Digital Library
Author Lehr, Thorsten Krüger, Thilo Wolf, Verena Bortolussi, Luca
Abstract We consider rule-based models extended with time-dependent reaction rates, a suitable formalism to describe the effect of drug administration on biochemical systems. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space of such models. Furthermore, we investigate a model of drug administration in the context of a plaque-formation process of Alzheimer's disease, a polymerization process best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying reaction network. Furthermore, time-dependent rates are needed to model the effect of drugs. We apply the simulation algorithm to study the efficacy of different drug administration policies.
Starting Page 53
Ending Page 60
Page Count 8
File Format PDF
ISBN 9781510801028
Language English
Publisher Association for Computing Machinery (ACM)
Publisher Date 2015-04-12
Publisher Place San Diego
Access Restriction Subscribed
Subject Keyword Rejection-based simulation algorithms Monte-carlo simulation Rule-based modelling Time-dependent rates Alzheimer's disease
Content Type Text
Resource Type Article
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