NDLI: Generation of novel Chagas vaccines: evolving studies/work in progress

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Generation of novel Chagas vaccines: evolving studies/work in progress

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Generation of novel Chagas vaccines: evolving studies/work in progress

Content Provider	ACM Digital Library
Author	Ardito, Matthew Martin, William Eickhoff, Christopher S. Hoft, Daniel F. Gustafson, Eric
Abstract	Chagas disease, caused by persistent chronic infection with the tropical parasite Trypanosoma cruzi, remains a severe cause of morbidity and mortality in the South American poor population. There are no Chagas vaccines for human use available nor in human clinical vaccine trials. We have previously shown that T cells alone provide protection to normally susceptible BALB/c mice against lethal systemic parasite challenge. The availability of 'humanized' mice (i.e., HLA DR1/A2 dual transgenic mice) allows us to perform similar studies eliciting data more relevant to human Chagas vaccine development. The goals of our evolving studies are to: 1) identify sequences predicted to bind multiple HLA alleles within a) the highly conserved functional (enzymatically active) trans-sialidase (TS) gene family members, b) the larger subset of non-functional TS genes, and c) the total gene subset expressed during human infection, 2) verify that predicted epitopes are presented by MHC during human T. cruzi infection, 3) prepare several DNA vaccines encoding multiple class I and class II parasite epitopes, and 4) perform immunization/challenge experiments in HLA-DR1/A2 dual transgenic mice to determine whether these novel T cell-driven vaccines induce immunity protective against acute lethal challenges as well as against chronic inflammation and disease.
Starting Page	579
Ending Page	583
Page Count	5
File Format	PDF
ISBN	9781450307963
DOI	10.1145/2147805.2147904
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2011-08-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Epitope prediction T cell Chagas disease Vaccine trypanosoma cruzi
Content Type	Text
Resource Type	Article

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