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  1. Proceedings of the KDD-09 Workshop on Statistical and Relational Learning in Bioinformatics (StReBio '09)
  2. Using random forests to uncover bivariate interactions in high dimensional small data sets
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Using random forests to uncover bivariate interactions in high dimensional small data sets
Identification of structurally important amino acids in proteins by graph-theoretic measures
Lift-based search for significant dependencies in dense data sets
Finding optimal parameters for edit distance based sequence classification is NP-hard
Multi-class protein fold recognition using large margin logic based divide and conquer learning
Protein sequence alignment and structural disorder: a substitution matrix for an extended alphabet
Handling missing values and censored data in PCA of pharmacological matrices
Comparing graph-based representations of protein for mining purposes
Can we improve on the identification of transcription factor binding sites?

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Using random forests to uncover bivariate interactions in high dimensional small data sets

Content Provider ACM Digital Library
Author Navarro, Hilario Arevalillo, Jorge M.
Abstract Random Forests (RF) is an ensemble method which has become widely accepted within the machine learning and bioinformatics communities in the last few years. Its predictive strength, along with some of the ingredients --- rich in information --- provided by the output, has made RF an efficient Data Mining tool for discovering patterns in data. In this paper we review the learning mechanism of RF within the classification setting and apply it to uncover bivariate interactions, carrying on useful information about an outcome, in high dimensional low sample data. We propose a divide and conquer search strategy in the variable space that benefits from the ranking of variable importances of RF at a first stage, along with the out of bag error rate (oob) of the ensemble at a second stage. The procedure combines both elements in order to capture difficult to uncover patterns in these type of data. We will show the performance of our procedure in some synthetic scenarios and will give a real application to a microarray data set in order to illustrate how it works.
Starting Page 3
Ending Page 6
Page Count 4
File Format PDF
ISBN 9781605586670
DOI 10.1145/1562090.1562091
Language English
Publisher Association for Computing Machinery (ACM)
Publisher Date 2009-06-28
Publisher Place New York
Access Restriction Subscribed
Subject Keyword Microarray data Bivariate interactions Random forests
Content Type Text
Resource Type Article
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