NDLI: Interactive exploration of coherent patterns in time-series gene expression data

Content Provider	ACM Digital Library
Author	Jiang, Daxin Pei, Jian Zhang, Aidong
Abstract	Discovering coherent gene expression patterns in time-series gene expression data is an important task in bioinformatics research and biomedical applications. In this paper, we propose an interactive exploration framework for mining coherent expression patterns in time-series gene expression data. We develop a novel tool, coherent pattern index graph, to give users highly confident indications of the existences of coherent patterns. To derive a coherent pattern index graph, we devise an attraction tree structure to record the genes in the data set and summarize the information needed for the interactive exploration. We present fast and scalable algorithms to construct attraction trees and coherent pattern index graphs from gene expression data sets. We conduct an extensive performance study on some real data sets to verify our design. The experimental results strongly show that our approach is more effective than the state-of-the-art methods in mining real gene expression data, and is scalable in mining large data sets.
Starting Page	565
Ending Page	570
Page Count	6
File Format	PDF
ISBN	1581137370
DOI	10.1145/956750.956820
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2003-08-24
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Coherent patterns Gene expression data Bioinformatics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interactive exploration of coherent patterns in time-series gene expression data