NDLI: Model-based design and analysis of a reconfigurable continuous-culture bioreactor

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Model-based design and analysis of a reconfigurable continuous-culture bioreactor

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Model-based design and analysis of a reconfigurable continuous-culture bioreactor

Content Provider	ACM Digital Library
Author	Vengurlekar, Amol Johnson, Taylor T. Salinas, Victor Nguyen, Luan Viet Nelson, Eric J. Zhang, Ruoshi White, Kristopher I.
Abstract	In this paper, we present a model-based design and analysis of prototype laboratory equipment used for growing bacteria under precisely controlled conditions for systems biology experiments. Continuous-culture bioreactors grow microorganisms continuously over periods as long as several months. Depending on the particular experiment, the reconfigurable continuous-culture bioreactor we model and analyze may operate as: (a) a chemostat with constant volume, (b) a turbidostat with constant bacterial concentration as observed through turbidity (optical density), or (c) a morbidostat with constant death-rate of bacteria. Such systems have interesting safety specifications such as not overflowing beakers, maintaining bacterial concentrations within ranges, etc., that must be maintained over long experimental periods. We develop preliminary controller and plant models and analyze them through simulation in Simulink/Stateflow (SLSF), and using reachability analysis in SpaceEx by translating the SLSF models to hybrid automata. The analysis indicates that the proposed design satisfies its regulation specifications for microorganism concentration may avoid error scenarios encountered in experiments with a prior design.
Starting Page	48
Ending Page	51
Page Count	4
File Format	PDF
ISBN	9781450328715
DOI	10.1145/2593458.2593469
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2014-04-14
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Simulation Model-based design Hybrid systems Verification
Content Type	Text
Resource Type	Article

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