NDLI: Automatic volume management for programmable microfluidics

Content Provider	ACM Digital Library
Author	Vijaykumar, T. N. Wereley, Steven Amin, Ahmed M. Jacobson, Stephen C. Thottethodi, Mithuna
Abstract	Microfluidics has enabled lab-on-a-chip technology to miniaturize and integrate biological and chemical analyses to a single chip comprising channels, valves, mixers, heaters, separators, and sensors. Recent papers have proposed programmable labs-on-a-chip as an alternative to traditional application-specific chips to reduce design effort, time, and cost. While these previous papers provide the basic support for programmability, this paper identifies and addresses a practical issue, namely, fluid volume management. Volume management addresses the problem that the use of a fluid depletes it and unless the given volume of a fluid is distributed carefully among all its uses, execution may run out of the fluid before all its uses are complete. Additionally, fluid volumes should not overflow (i.e., exceed hardware capacity) or underflow (i.e., fall below hardware resolution). We show that the problem can be formulated as a linear programming problem (LP). Because LP's complexity and slow execution times in practice may be a concern, we propose another approach, called DAGSolve, which over-constrains the problem to achieve linear complexity while maintaining good solution quality. We also propose two optimizations, called cascading and static replication, to handle cases involving extreme mix ratios and numerous fluid uses which may defeat both LP and DAGSolve. Using some real-world assays, we show that our techniques produce good solutions while being faster than LP.
Starting Page	56
Ending Page	67
Page Count	12
File Format	PDF
ISSN	03621340 15581160
DOI	10.1145/1379022.1375590
Journal	ACM SIGPLAN Notices (SIGP)
Volume Number	43
Issue Number	6
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	1983-05-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fluid volume management Microfluidics Programmable lab on a chip
Content Type	Text
Resource Type	Article
Subject	Computer Graphics and Computer-Aided Design Software

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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