Stromal Derived Factor Inhibition and Cxcr4 Blockade

Content Provider	The Lens
Abstract	The invention relates to inhibition of SDF-1α expression in subacromial bursa cells by CXCR-4 inhibitors. Bursal cell migration in response to SDF-α stimulation is also decreased in the presence of CXCR4 inhibitors. Accordingly, provided are methods for treating or ameliorating a musculoskeletal disorder.
Related Links	https://www.lens.org/lens/patent/011-996-672-733-795/frontpage
Language	English
Publisher Date	2019-10-24
Access Restriction	Open
Content Type	Text
Resource Type	Patent
Jurisdiction	United States of America
Date Applied	2019-07-03
Applicant	Rhode Island Hospital
Application No.	201916502693
Claim	A method for treating a tendon injury in a subject, comprising administering to said subject a compound that binds to CXCR4, wherein said compound is a peptide inhibitor, and wherein said peptide inhibitor comprises a sequence of SEQ ID NO: 7, 8, or 9, thereby treating said tendon injury, wherein said tendon injury comprises a tendon rupture or tear, wherein said tendon comprises an Achilles tendon, an elbow tendon, a patellar tendon, a finger flexor or extensor tendon, or a toe digital flexor or extensor tendon. The method of claim 1 , wherein said compound is administered locally to a musculoskeletal tissue, said tissue comprising the rupture or tear. - 17 . (canceled) The method of claim 1 , wherein treating said tendon injury comprises healing the tendon. The method of claim 1 , wherein treating said tendon injury comprises reducing inflammation. The method of claim 1 , wherein said tendon injury comprises a tendon rupture. The method of claim 1 , wherein said tendon injury comprises a tendon tear. The method of claim 1 , wherein the tendon comprises an Achilles ten-don. The method of claim 1 , wherein the tendon comprises an elbow tendon or a patellar tendon. The method of claim 1 , wherein the tendon comprises a finger flexor or extensor tendon or a toe digital flexor or extensor tendon.
CPC Classification	HETEROCYCLIC COMPOUNDS Preparations For Medical; Dental Or Toiletry Purposes Specific Therapeutic Activity Of Chemical Compounds Or Medicinal Preparations ACYCLIC OR CARBOCYCLIC COMPOUNDS
Extended Family	167-473-361-149-828 011-996-672-733-795 083-460-826-547-802
Patent ID	20190322633
Inventor/Author	Blaine Theodore A
IPC	C07D295/135 A61K31/135 A61K31/497 A61K38/10 C07C211/27 C07C237/30 C07C257/18 C07D233/64 C07D233/88
Status	Discontinued
Owner	Rhode Island Hospital Blaine Theodore A
Simple Family	167-473-361-149-828 011-996-672-733-795 083-460-826-547-802
CPC (with Group)	C07D295/135 A61K31/135 A61K31/497 A61K38/10 A61P19/00 A61P21/00 C07D233/64 C07D233/88 C07C211/27 C07C237/30 C07C257/18
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent Application Publication