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Silicone Hydrogel Contact Lenses
| Content Provider | The Lens |
|---|---|
| Related Links | https://www.lens.org/lens/patent/011-976-591-516-459/frontpage |
| Language | English |
| Publisher Date | 2019-04-03 |
| Access Restriction | Open |
| Alternative Title | Silikonhydrogel-kontaktlinsen Lentilles De Contact En Silicone-hydrogel |
| Content Type | Text |
| Resource Type | Patent |
| Date Applied | 2012-02-23 |
| Agent | Abel & Imray |
| Applicant | Coopervision Int Holding Co Lp |
| Application No. | 12752944 |
| Claim | A silicone hydrogel contact lens, comprising: a polymeric lens body that is the reaction product of a polymerizable composition, characterized in that said polymerizable composition comprises (a) a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R 1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (3) is independently either a hydrogen atom or a methyl group; (b) at least one vinyl ether-containing cross-linking agent, wherein the at least one vinyl ether-containing cross-linking agent comprises a vinyl-ether containing cross-linking agent having at least one ethylene glycol unit present in its molecular structure; and (c) at least one methacrylate-containing cross-linking agent. The silicone hydrogel contact lens of claim 1, wherein the at least one vinyl ether-containing cross-linking agent is present in the polymerizable composition in an amount from 0.01 unit parts by weight to 0.2 unit parts by weight. The silicone hydrogel contact lens of claim 1 or claim 2, wherein the at least one vinyl ether-containing cross-linking agent comprises a divinyl ether-containing crosslinking agent; or wherein the at least one vinyl ether-containing cross-linking agent comprises tri(ethylene glycol) divinyl ether (TEGDVE), or di(ethylene glycol) divinyl ether, or a form of poly(ethylene glycol) divinyl ether having from 4 to 10 ethylene glycol units, or a form of poly(ethylene glycol) divinyl ether having more than 10 ethylene glycol units, or 1,4-butanediol divinyl ether, or any combination thereof. The silicone hydrogel contact lens of any preceding claim, wherein the polymerizable composition further comprises at least one hydrophilic amide monomer having one N-vinyl group. The silicone hydrogel contact lens of claim 4, wherein a ratio of total unit parts by weight of hydrophilic amide monomers present in the polymerizable composition to a total unit parts by weight of vinyl ether-containing cross-linking agents present in the polymerizable composition is a ratio of at least 200:1. The silicone hydrogel contact lens of any preceding claim, wherein the first siloxane monomer has a number average molecular weight of from 400 daltons to 700 daltons. The silicone hydrogel contact lens of any preceding claim, wherein the first siloxane monomer is represented by formula (3) where m of formula (3) is 4, n of formula (3) is 1, R 1 of formula (3) is a butyl group, and each R 2 of formula (3) is independently either a hydrogen atom or a methyl group. The silicone hydrogel contact lens of any preceding claim, wherein the polymerizable composition further comprises a second siloxane monomer having a number average molecular weight greater than 7,000 daltons. The silicone hydrogel contact lens of any preceding claim, wherein the polymerizable composition further comprises a second siloxane monomer represented by formula (4): wherein R 1 of formula (4) is selected from either a hydrogen atom or a methyl group; R 2 of formula (4) is selected from either of hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; m of formula (4) represents an integer of from 0 to 10; n of formula (4) represents an integer of from 4 to 100; a and b represent integers of 1 or more; a+b is equal to 20-500; b/(a+b) is equal to 0.01-0.22; and the configuration of siloxane units includes a random configuration. The silicone hydrogel contact lens of claim 9, wherein the second siloxane monomer is a monomer represented by formula (4) where m of formula (4) is 0, n of formula (4) is an integer from 5 to 15, a is an integer from 65 to 90, b is an integer from 1 to 10, R 1 of formula (4) is a methyl group, and R 2 of formula (4) is either a hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms. A batch of silicone hydrogel contact lenses, comprising a plurality of the contact lens of any preceding claim, wherein the batch of silicone hydrogel contact lenses have an average dimensional stability variance of less than plus or minus three percent (±3.0%), such as less than plus or minus two percent (±2.0%), where the average dimensional stability variance is the variance in a value of a physical dimension when measured at an initial time point within one day of a manufacturing date of the batch of lenses, and at a second time point, where the second time point is from two weeks to seven years after the initial time point when the batch is stored at room temperature, or, when the batch is stored at a higher temperature, the second time point is a time point representative of storage of the batch from two weeks to seven years at room temperature, said average dimensional stability variance being an average of the dimensional stability variance determined for at least 20 individual lenses of the batch by the following equation (A): A batch of silicone hydrogel contact lenses, comprising a plurality of the contact lens recited in any one of claims 1 to 11, wherein the batch of silicone hydrogel contact lenses has, when fully hydrated, an average equilibrium water content (EWC) from about 30% wt/wt to about 70% wt/wt, or an average oxygen permeability of at least 55 barrers, or a tensile modulus from about 0.2MPa to about 0.9MPa, or any combination thereof, based on averages of values determined for at least 20 individual lenses of the batch. A method of manufacturing a silicone hydrogel contact lens, comprising: providing a polymerizable composition; polymerizing the polymerizable composition in a contact lens mold assembly to form a polymeric contact lens body; contacting the polymeric contact lens body with a washing liquid to remove extractable material from the polymeric contact lens body; and packaging the polymeric contact lens body in a contact lens packaging solution in a contact lens package, characterized in that said polymerizable composition comprises (a) a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R 1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (3) is independently either a hydrogen atom or a methyl group; (b) at least one vinyl ether-containing cross-linking agent, and wherein the at least one vinyl ether-containing cross-linking agent comprises a vinyl-ether containing cross-linking agent having at least one ethylene glycol unit preset in its molecular structure; and (c) at least one methacrylate-containing cross-linking agent. The method of claim 13, wherein the silicone hydrogel contact lens is not contacted by a volatile organic solvent during the manufacturing process. The method of claim 13 or claim 14, further comprising repeating the steps to produce a plurality of the silicone hydrogel contact lenses having an average dimensional stability variance of less than plus or minus three percent (±3.0%) over a time period from two weeks to seven years when stored at room temperature, or, when stored under accelerated shelf life testing conditions, for a time period and temperature equivalent to storage from two weeks to seven years at room temperature, said average dimensional stability variance being an average of the dimensional stability variance determined for at least 20 individual lenses of the batch by the following equation (A): |
| CPC Classification | OPTICAL ELEMENTS; SYSTEMS OR APPARATUS MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS COMPOSITIONS OF MACROMOLECULAR COMPOUNDS SPECTACLES;SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES;CONTACT LENSES WORKING-UP;GENERAL PROCESSES OF COMPOUNDING;AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B; C08C; C08F; C08G or C08H |
| Extended Family | 132-017-278-904-66X 199-919-058-829-796 082-167-225-983-79X 067-236-403-295-360 094-275-096-553-593 152-601-543-552-254 159-175-254-761-16X 111-538-708-186-453 013-118-037-104-942 098-299-370-888-022 134-064-412-213-961 137-019-106-187-159 123-338-899-545-998 160-223-367-363-976 003-140-914-139-230 093-781-703-009-983 159-927-604-396-553 047-930-565-090-100 053-202-658-004-517 051-955-037-854-168 033-189-611-705-237 120-442-542-267-383 011-976-591-516-459 051-078-236-444-522 019-348-734-818-280 048-562-236-093-861 166-318-071-109-872 099-256-778-873-488 106-016-763-055-211 |
| Patent ID | 2681617 |
| Inventor/Author | Liu Yuwen Hong Ye Ge Junhao Xu Yuan Chen Charlie Francis Charles A Yao Li Back Arthur |
| IPC | G02C7/04 C08F226/00 C08F236/20 C08F283/06 C08F283/12 C08J11/02 C08L51/08 G02B1/04 |
| Status | Active |
| Owner | Coopervision International Limited; Gb Coopervision International Limited Coopervision International Limited, Gb Coopervision International Limited, Segenswort, Gb |
| Simple Family | 132-017-278-904-66X 199-919-058-829-796 082-167-225-983-79X 067-236-403-295-360 094-275-096-553-593 152-601-543-552-254 159-175-254-761-16X 111-538-708-186-453 013-118-037-104-942 098-299-370-888-022 134-064-412-213-961 137-019-106-187-159 123-338-899-545-998 160-223-367-363-976 003-140-914-139-230 093-781-703-009-983 159-927-604-396-553 047-930-565-090-100 053-202-658-004-517 051-955-037-854-168 033-189-611-705-237 120-442-542-267-383 011-976-591-516-459 051-078-236-444-522 019-348-734-818-280 048-562-236-093-861 166-318-071-109-872 099-256-778-873-488 106-016-763-055-211 |
| CPC (with Group) | G02B1/043 C08F283/065 C08L51/085 C08F230/08 G02C7/04 C08L51/08 C08F226/00 C08F236/20 C08F283/126 C08J11/02 |
| Issuing Authority | United States Patent and Trademark Office (USPTO) |
| Kind | Patent/Patent 1st level of publication/Inventor's certificate |
