System and Method for Semi-projective Quantitative Flow Imaging Using Accelerated Arterial Spin-labeled Cine Mri

Content Provider	The Lens
Abstract	A system and method for controlling a magnetic resonance imaging (MRI) system to create magnetic resonance (MR) cine angiograms of a subject. The method includes controlling the MRI system to acquire MR data from the subject by performing at least one cine acquisition pulse sequence having a plurality of acquisition RF pulse modules applied at constant intervals throughout a cardiac cycle, and at least one labeling pulse sequence including a first and a second α/2 module and a labeling RF pulse module for labeling a region of inflowing arterial flow through a vessel of interest. The method further includes reconstructing the MR data to form a series of cine frames that form a cine angiogram, subtracting at least one cine frame from other cine frames reconstructed from the MR data, and displaying the MR cine angiogram of the vessel of interest.
Related Links	https://www.lens.org/lens/patent/010-990-346-896-122/frontpage
Language	English
Publisher Date	2019-12-05
Access Restriction	Open
Content Type	Text
Resource Type	Patent
Jurisdiction	United States of America
Date Applied	2019-04-26
Applicant	Northshore Univ Healthsystem
Application No.	201916395835
Claim	A method for controlling a magnetic resonance imaging (MRI) system to create magnetic resonance (MR) cine angiograms of a subject, the method comprising: (a) monitoring a cardiac cycle of the subject; (b) controlling the MRI system to acquire MR data from the subject by performing at least one cine acquisition pulse sequence by: (i) applying a plurality of acquisition radiofrequency (RF) pulse modules at constant intervals throughout the cardiac cycle between a labeling interval to acquire the MR data using a radial sampling of k-space; (ii) during the labeling interval, labeling a region of inflowing arterial flow through a vessel of interest in the subject by performing at least one labeling pulse sequence including a first α/2 RF pulse module, a labeling RF pulse module, and a second α/2 RF pulse module, wherein a denotes a RF flip angle of the acquisition RF pulse module; (c) reconstructing the MR data to form a series of cine frames that form an MR cine angiogram of the subject; (d) subtracting at least one cine frame reconstructed from the MR data from other cine frames reconstructed from the MR data; and (e) displaying the MR cine angiogram of the vessel of interest. The method of claim 1 , wherein the cine acquisition pulse sequence is a 2D cine acquisition pulse sequence which samples k-space using a slice thickness that is at least 20% larger than a cross-sectional dimension of the vessel of interest. The method of claim 1 , wherein the cine acquisition pulse sequence samples k-space with a temporal resolution of each cine frame of at least 20 Hz. The method of claim 1 , wherein labeling the region of inflowing arterial flow includes labeling a labeling slice having a thickness of 50 mm or less. The method of claim 2 , wherein the acquisition RF pulse module has a time-bandwidth product having a numerical value that is at least 1/12 of the thickness of the imaging slice as expressed in millimeters and not less than 1.0. The method of claim 1 , wherein the cine angiogram represents arterial flow through the vessel of interest during the cardiac cycle. The method of claim 6 , wherein displaying includes illustrating an instantaneous flow velocity of the arterial flow, wherein the instantaneous flow velocity is a ratio of a distance traveled by a leading edge of the arterial flow and the temporal resolution of the cine frames. The method of claim 1 , wherein the radial sampling of k-space uses equidistant azimuthal sampling angles relative to adjacent radial samples of k-space. The method of claim 1 , wherein the labeling pulse sequence is applied during alternate cardiac cycles. The method of claim 1 , wherein a slice-selection gradient for the labeling RF pulse module is turned off on alternative cardiac cycles to compensate for magnetization transfer effects. The method of claim 1 , wherein acquiring the MR data includes performing at least one of a radial undersampling or simultaneous multi-slice acquisition or the reconstructing includes performing a compressed-sensing-based reconstruction. The method of claim 1 , wherein the labeling pulse sequence is performed at least twice in each cardiac cycle. The method of claim 1 , wherein the cine acquisition pulse sequence is a 3D cine acquisition pulse sequence which uses a stack-of-stars k-space trajectory. The method of claim 1 , wherein at least one motion correction technique is used to avoid subtraction artifacts due to patient motion. The method of claim 14 , wherein navigator gating is one of the at least one motion correction techniques. The method of claim 1 , wherein the labeling RF pulse module is an inversion RF pulse module having a RF flip angle of 180 degrees. The method of claim 1 , wherein the second α/2 RF pulse module has a polarity that is opposite the first α/2 RF pulse module. The method of claim 1 , wherein the acquisition RF pulse module is a fast interrupted steady-state (FISS RF) pulse module. The method of claim 18 , wherein the first α/2 RF pulse module and the second α/2 RF pulse module of the labeling pulse sequence are shared with adjacent FISS RF pulse modules. The method of claim 1 , further comprising grouping the MR data using the monitoring of the cardiac cycle of the subject to retrospectively gate MR data based on a phase of the cardiac cycle during which MR data was acquired. A magnetic resonance imaging (MRI) system comprising: a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject including a vessel of interest arranged in the MRI system; a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field; a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from the subject; a computer system programmed to generate a plurality of differently-weighted images of a subject by: (a) performing at least one cine acquisition pulse sequence by: (i) applying a plurality of acquisition radiofrequency (RF) pulse modules at constant intervals throughout the cardiac cycle between a labeling interval to acquire the MR data using a radial sampling of k-space; (ii) during the labeling interval, labeling a region of inflowing arterial flow through a vessel of interest in the subject by performing at least one labeling pulse sequence including a first α/2 RF pulse module, a labeling RF pulse module, and a second α/2 RF pulse module, wherein a denotes a RF flip angle of the acquisition RF pulse module, and the second α/2 RF pulse module; (b) reconstructing the MR data to form a series of cine frames that form an MR cine angiogram of the subject; (c) subtracting at least one cine frame reconstructed from the MR data from other cine frames reconstructed from the MR data; and a display coupled to the computer system to display the MR cine angiogram of the vessel of interest. The system of claim 21 , wherein the cine acquisition pulse sequence is a 2D cine acquisition pulse sequence which samples k-space using a slice thickness that is at least 20% larger than a cross-sectional dimension of the vessel of interest. The system of claim 21 , wherein the cine acquisition pulse sequence samples k-space with a temporal resolution of each cine frame of at least 20 Hz. The system of claim 23 , wherein the acquisition RF pulse module has a time-bandwidth product having a numerical value that is at least 1/12 of the thickness of the labeling slice as expressed in millimeters and not less than 1.0. The system of claim 21 , wherein labeling the region of inflowing arterial flow includes labeling a labeling slice having a thickness of 50 mm or less. The system of claim 21 , wherein cine angiogram represents arterial flow through the vessel of interest during the cardiac cycle. The system of claim 26 , wherein displaying includes illustrating an instantaneous flow velocity of the arterial flow, wherein the instantaneous flow velocity is a product of a distance traveled by a leading edge of the arterial flow and the temporal resolution of the cine frames. The system of claim 21 , wherein the radial sampling of k-space uses equidistant azimuthal sampling angles relative to adjacent radial samples of k-space. The system of claim 21 , wherein the labeling pulse sequence is applied during alternate cardiac cycles. The system of claim 21 , wherein a slice-selection gradient for the labeling RF pulse module is turned off on alternative cardiac cycles to compensate for magnetization transfer effects. The system of claim 21 , wherein acquiring the MR data includes performing at least one of a radial undersampling or simultaneous multi-slice acquisition or the reconstructing includes performing a compressed-sensing-based reconstruction. The system of claim 21 , wherein the labeling pulse sequence is performed at least twice in each cardiac cycle. The system of claim 21 , wherein the cine acquisition pulse sequence is a 3D cine acquisition which uses a stack-of-stars k-space trajectory. The system of claim 21 , wherein at least one motion correction techniques is used to avoid subtraction artifacts due to patient motion. The system of claim 34 , wherein navigator gating is one of the at least one motion correction techniques The system of claim 21 , wherein the labeling RF pulse module is an inversion RF pulse module having a RF flip angle of 180 degrees. The system of claim 21 , wherein the acquisition RF pulse module is a FISS RF pulse module. The system of claim 37 , wherein the first α/2 RF pulse module and the second α/2 RF pulse module of the labeling pulse sequence are shared with adjacent FISS RF pulse modules. The system of claim 21 , further comprising grouping the MR data using the monitoring of the cardiac cycle of the subject to retrospectively gate MR data based on a phase of the cardiac cycle during which MR data was acquired.
CPC Classification	Measuring Electric Variables;Measuring Magnetic Variables
Extended Family	018-752-999-883-457 010-990-346-896-122
Patent ID	20190369196
Inventor/Author	Edelman Robert R Koktzoglou Ioannis
IPC	G01R33/563 G01R33/48 G01R33/56 G01R33/561 G01R33/565
Status	Active
Owner	Northshore University Healthsystem
Simple Family	018-752-999-883-457 010-990-346-896-122
CPC (with Group)	G01R33/56325 G01R33/4824 G01R33/5614 G01R33/56316 G01R33/5635 G01R33/56509 G01R33/5608 G01R33/5613
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent Application Publication