Thermostable Composition with Antiviral and Antibacterial Activity and Use Thereof

Content Provider	The Lens
Abstract	A series of inventions refers to biotechnology, pharmaceutics, medicine, cosmetology, veterinary and can be used for prevention and treatment of bacterial and viral diseases in humans and animals, and also relates to the production of a wide range of sanitary and medicinal products. A thermostable composition with antiviral and antimicrobial activity and its use as a biologically active component for the production of sanitary and hygienic products as well as for protection from bacterial and viral infections has been claimed. In particular, the thermostable composition is a lyophilized powder containing the following components per 1 g of the composition: recombinant interferon gamma human with the activity from 500,000 to 2,000,000 IU / g 0.03 to 0.12 mg lysostaphin with the activity from 50 to 200 U / g 0.17 to 0.68 mg methoxy polyethylene glycol 30 - 150 mg sodium alginate 10 - 25 mg sodium dihydrophosphate dihydrate 120 - 250 mg citric acid 35-110 mg dextran q.s. The proposed thermostable composition can be used as a component of oral cavity care products, toothpastes, sanitary-hygienic products, a clothes conditioner and condom lubricant and in a number of medicinal products and drugs.
Related Links	https://www.lens.org/lens/patent/010-946-191-722-751/frontpage
Language	English
Publisher Date	2019-05-22
Access Restriction	Open
Alternative Title	Thermostabile Zusammensetzung Mit Antiviraler Und Antibakterieller Wirkung Und Verwendung Davon Composition Thermostable Possédant Une Action Antivirale Et Antibactérienne, Et Utilisation De Celle-ci
Content Type	Text
Resource Type	Patent
Date Applied	2017-09-25
Agent	Bucher, Ralf Christian
Applicant	Chumburidze Georgy Georgievich
Application No.	17904349
Claim	A thermostable composition possessing antiviral and antibacterial activity represents a lyophilized product containg the following components in 1 g of the comosition: human recombinant interferon gamma with activity of 500000 to 2000000IU/g0.03 - 0.12 mg lysostaphin with activity of 50 to 200 U/g 0.17 - 0.68 mg methoxy polyethylene glycol 30 - 150 mg sodium alginate 10 - 25 mg sodium dihydrophosphate dihydrate 120 - 250 mg citric acid 35 - 110 mg dextran q.s. A thermostable composition according to claim 1 characterized in that the lyophilized product is obtained from a solution with pH 5-7. A thermostable composition according to claim 1 characterized in that the recombinant gamma interferon human is obtained from E. coli producer strain transformed with plasmid pGIF315. A thermostable composition according to claim 1 characterized in that dextran with a molecular weight of 60.000 or 70.000 or a mixture of dextran with these molecular weights is used. A thermostable composition according to claim 1 characterized in that methoxypolyethylene glycol having a molecular weight of 2000 to 5000 or a mixture of methoxypolyethylene glycol with these molecular weights is used. A thermostable composition according to claim 1 characterized in that recombinant lysostaphin is used as lysostaphin. An oral cavity care product representing an aqueous solution of the thermostable composition according to any one of claims 1-6. An oral cavity care product according to claim 7 characterized in that the aqueous solution has the activity of recombinant interferon gamma human from 200 to 1000 IU / ml and that of lysostaphin from 0.02 to 0.1 U / m An oral cavity care product according to claim 8 characterized in that it additionally contains sorbitol, sodium chloride and a preservative. An oral cavity care product according to claim 8 characterized in that it additionally contains povidone, potassium sorbate, and / or potassium lactate, flavoring agent and a preservative. An oral cavity care product according to claim 10 characterized in that it represents a spray. A toothpaste comprises the thermostable composition according to any of claims 1- 6 and suitable fillers used to prepare toothpastes, and the toothpaste has the activity of human recombinant interferon gamma from 200 to 1000 IU / g and that of lysostaphin from 0.02 to 0.1 ED / g, with the following ratio of components (mass%): thermostable composition 0.01 - 0.2 % wt. suitable fillerq.s. A toothpaste according to claim 12 characterized in that it additionally comprises vitamins and / or antifungal agents or a mixture them. A sanitary-hygienic product contains a fabric base and the thermostable composition according to any of claims 1-6, and the product has the activity of human recombinant interferon gamma from 5000 to 20,000 IU / cm 2 and that of lysostaphin from 0.5 to 2 U / cm 2 with the following ratio of components (mass%): thermostable composition 0.25 - 4 fabric base q.s. A sanitary-hygienic product according to claim 14 characterized in that it additionally contains carboxymethylcellulose, sodium alginate, trehalose, a preservative, which before mixing with the thermostable composition according to any of items from 1 to 6 are dissolved in water and the fabric base is impregnated with the prepared aqueous solution and then dried to a moisture content of 1-7 wt% with the following ratio of components in the end product (wt%): thermostable composition 0.25 - 4 carboxymethyl cellulose 5 - 40 trehalose 0.05-0.5 sodium alginate 1 - 5 preservative 0.1 - 0.5 fabric base q.s. A sanitary-hygienic product according to claim 14 characterized in that the thermostable composition according to any of claims 1-6 and is applied to a fabric base. A sanitary-hygienic product according to claim 14 characterized in that the fabric base consists of cotton and / or cellulose and / or viscose and / or synthetic materials or a mixture of them. A sanitary-hygienic product according to any of claims from 14 to 17 characterized in that it is preferably represents a wipe, face mask, paper towel and handkerchiefs. A sanitary-hygienic product according to claim 18 characterized in that it is packaged in an individual sealed pack or in a batch of hermetic packs. A sanitary-hygienic wet product comprising a fabric base impregnated with the thermostable composition according to any of claims 1-6 dissolved in an aqueous solution containing carboxymethyl cellulose, sodium alginate and a preservative and dried to a moisture content of 10 to 20% by weight, the product has the activity of human recombinant interferon gamma 4000-16000 IU / cm 2 and that of lysostaphin 0.4 - 1.6 U / cm 2 with and the following ratio of components in the end product (mass%): thermostable composition 0.2 - 3.2 carboxymethylcellulose 10 - 25 sodium alginate 2 - 10 preservative 0.05 - 0.15 absorbent substrate q.s. A sanitary-hygienic wet product according to claim 20 characterized in that it additionally contains glycerin and / or thioglycol and / or antifungal agents and / or vitamins and / or dye and / or flavoring or a mixture them, and the absorbent substrate is composed of cotton, and / or viscose, and / or synthetic materials or a mixture them. A sanitary-hygienic wet product according to any of claims 20-21 characterized in that it is preferably represents a wipe, wet toilet paper, sanitary wipe, and the product is packaged in an individual sealed pack or in a batch of hermetic packs. A disposable absorbent product containing a substrate and a sanitary hygienic product according to any of claims 14-19, and a weight-to-weight ratio basic substrate: product being (5-10): (1-5). A disposable absorbent product according to claim 23 characterized in that the absorbent product represents preferably a tampon, hygienic liner, daily hygienic liner. A disposable absorbent product according to claim 24 characterized in that the product is packaged into an individual sealed pack or in a batch of sealed packs. A skin care product containing a cosmetically suitable base and the thermostable composition according to any of claims 1-6, and the product has the activity of human recombinant interferon gamma from 500 to 2000 IU / g and that of lysostaphin from 0.05 to 0.2 U / g with the following ratio of the components in the end product (mass%): thermostable composition 0.025-0.4 cosmetically suitable base q.s. A skin care product according to claim 26 characterized in that the cosmetically suitable base represents a gel or a fat base, or an aqueous base, or a powder base and the product represents a cream, gel, jelly, powder, lotion, spray or a mask. A skin care product according to claim 27 characterized in that it contains talc and / or aerosil as a powder base. A skin care product according to claim 26 characterized in that it additionally contains spermaceti and / or vitamins and / or mineral salts and / or antifungal agents or a mixture of them. A skin care product according to any of claims 26-29 characterized in that it represents a product for veterinary use. A sanitary-hygienic product containing an acceptable liquid base and the thermostable composition according to any of claims 1-6, and the product has the activity of human recombinant interferon gamma from 500 to 100,000 IU / ml and that of lysostaphin from 0.05 to 10 U / ml with the following ratio of the components in the end product (mass%): thermostable composition 0.025 - 20 acceptable liquid base q.s. A sanitary-hygienic product according to claim 31 characterized in that it represents a spray and additionally contains trehalose, a preservative and PEG 400 and / or triethanolamine to provide pH 6.0-8.0. A sanitary-hygienic product according to claim 31 characterized in that it is prepared in the form of gel and additionally contains carboxymethylcellulose, sodium alginate, a preservative, trehalose and PEG 400 and / or triethanolamine to provide pH 6.0 - 8.0. A sanitary-hygienic product according to any of claims 31-33 characterized in that it is the product for surface treatment. A sanitary-hygienic product according to claim 32 characterized in that it represents a product for clothes treatment. A laundry conditioner comprises an acceptable liquid base and the thermostable composition according to any of claims 1-6, at the same time the conditioner has the activity of recombinant interferon gamma human 2000-10,000 IU / ml and that of lysostaphin 0.2-1 U / mL with the following ratio of components in the end product (mass%): thermostable composition 0.1 - 2 acceptable liquid base q.s. A condom lubricant contains the thermostable composition according to any of claims 1-6 and pharmaceutically acceptable additives, at the same time the product has the activity of recombinant interferon gamma human from 5 to 50 U / g and that of lysostaphin from 0.0005 to 0.005 U/ g with the following ratio of components in the end product (mass%): thermostable composition 0.00025 - 0.01 pharmaceutically acceptable target additives q.s. A condom lubricant according to claim 37 characterized in that it additionally contains vitamins and / or antifungal agents. A medicinal product comprising a pharmaceutically acceptable base and the thermostable composition according to any of claims 1-6, and the product has the activity of recombinant interferon gamma human from 5000 to 100,000 IU / g and that of lysostaphin from 0.5 to 10 U / g, with the following ratio of components in the end product (mass%): thermostable composition 0.25 - 20 pharmaceutically acceptable base q.s. A medicinal product according to claim 39 characterized in that it represents either a suppository, spray, ointment, gel or a lyophilized powder. A medicinal product comprises a fabric base and the thermostable composition according to any of claims 1-6; the product has the activity of recombinant interferon gamma human 5000-2000 IU / cm 2 and that of lysostaphin 0.5-2 U / cm 2 and the following ratio of components (wt%): thermostable composition 0.25 - 4 fabric base q.s. A medicinal product according to claim 41 characterized in that it additionally contains carboxymethylcellulose, sodium alginate, trehalose and a preservative, which prior to mixing with the thermostable composition according to any of items from 1 to 6 are dissolved in water, and the fabric base is impregnated with the obtained aqueous solution and then dried to a moisture content from 1 to 7% by weight with the following ratio of components in the end product (wt%): thermostable composition 0.25 - 4 carboxymethyl cellulose 5 - 40 trehalose 0.05-0.5 sodium alginate 1 - 5 preservative 0.1 - 0.5 fabric base q.s. A medicinal product according to claim 41 characterized in that the thermostable composition according to any of claims 1-6 is applied to the fabric base. A medicinal product according to claim 41 characterized in that the fabric base is made of cotton and / or cellulose and / or viscose and / or synthetic materials or a mixture them, and the product is preferably used as a face mask, bandage, disposable gloves or a sponge for topical use. A medicinal product according to claim 44 characterized in that it is packaged in individual sealed packs or in a batch of sealed packs.
CPC Classification	Preparations For Medical; Dental Or Toiletry Purposes Methods Or Apparatus For Sterilising Materials Or Objects In General;Disinfection; Sterilisation Or Deodorisation Of Air;Chemical Aspects Of Bandages; Dressings; Absorbent Pads Or Surgical Articles;Materials For Bandages; Dressings; Absorbent Pads Or Surgical Articles Specific Therapeutic Activity Of Chemical Compounds Or Medicinal Preparations Specific Use Of Cosmetics Or Similar Toiletry Preparations Filters Implantable Into Blood Vessels; Prostheses; Devices Providing Patency To; Or Preventing Collapsing Of; Tubular Structures Of The Body; E.G. Stents; Orthopaedic; Nursing Or Contraceptive Devices; Fomentation; Treatment Or Protection Of Eyes Or Ears; Bandages; Dressings Or Absorbent Pads; First-Aid Kits Preservation Of Bodies Of Humans Or Animals Or Plants Or Parts There of; Biocides; E.G. As Disinfectants; As Pesticides Or As Herbicides; Pest Repellants Or Attractants; Plant Growth Regulators
Extended Family	168-084-927-345-164 010-946-191-722-751 052-978-353-013-596 063-843-905-604-716 075-713-945-310-94X 157-915-470-034-483
Patent ID	3485899
Inventor/Author	Chumburidze Georgy Georgievich
IPC	A61K38/19 A41B15/00 A61F13/15 A61K9/08 A61K9/10 A61K31/25 A61K31/721 A61K47/12 A61K47/36 A61L15/44 A61P31/04 A61P31/12 A61Q11/00
Status	Discontinued
Simple Family	168-084-927-345-164 010-946-191-722-751 063-843-905-604-716 052-978-353-013-596 075-713-945-310-94X 157-915-470-034-483
CPC (with Group)	A61K38/164 A61K9/0014 A61K9/0031 A61K9/19 A61K38/217 A61L15/44 A61L15/46 A61L2300/252 A61L2300/254 A61L2300/404 A61L2300/408 A61L2300/45 A61L2300/802 A61P31/04 A61P31/12 A61Q11/00 A61F13/15 A61K9/08 A61K9/10 A61K38/48 A61K47/12 A61K47/36 A01N25/34 A01N63/50 A61K8/24 A61K8/365 A61K8/64 A61K8/66 A61K8/73 A61K8/733 A61K8/86 A61K38/4886 A61K47/02 A61K47/10 A61Q19/00
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent Application Publication