Composition for Epimerization of Non-phosphorylated Hexose Comprising Sugar Epimerases Derived from Thermophiles

Content Provider	The Lens
Abstract	The present invention relates to a composition for epimerization of a non-phosphorylated hexose, comprising sugar epimerases derived from thermophiles, and a method for preparing a non-phosphorylated hexose epimer using the composition. The sugar epimerases derived from thermophiles according to the present invention can effectively catalyze an epimerization reaction of a non-phosphorylated hexose and can easily produce an epimer form of the non-phosphorylated hexose, in particular a rare sugar hexose, and thus can be usefully utilized in the pharmaceutical and food industry.
Related Links	https://www.lens.org/lens/patent/010-890-653-880-472/frontpage
Language	English
Publisher Date	2019-12-03
Access Restriction	Open
Content Type	Text
Resource Type	Patent
Jurisdiction	United States of America
Date Applied	2018-01-30
Agent	Bret E. Field Bozicevic, Field & Francis Llp
Applicant	Cj Cheiljedang Corp
Application No.	201815883885
Claim	A method for preparing a non-phosphorylated hexose epimer, the method comprising treating a non-phosphorylated hexose with UDP-glucose-4-epimerase from Thermotoga maritima, wherein the non-phosphorylated hexose epimer is a C2 or C4 epimer of the non-phosphorylated hexose epimer. The method of claim 1 , wherein the non-phosphorylated hexose is an aldohexose or a ketohexose. The method of claim 2 , wherein the aldohexose is at least one selected from the group consisting of allose, altrose, glucose, mannose, gulose, idose, talose, and galactose. The method of claim 2 , wherein the ketohexose is at least one selected from the group consisting of fructose, psicose, sorbose, and tagatose. The method of claim 1 , wherein the non-phosphorylated hexose is tagatose and epimer of the non-phosphorylated hexose is fructose. The method of claim 1 , wherein the non-phosphorylated hexose is fructose and epimer of the non-phosphorylated hexose is tagatose. The method of claim 1 , wherein the non-phosphorylated hexose is glucose and epimer of the non-phosphorylated hexose is mannose. The method of claim 1 , wherein the non-phosphorylated hexose is galactose and epimer of the non-phosphorylated hexose is glucose.
CPC Classification	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE MICROORGANISMS OR ENZYMES;COMPOSITIONS THEREOF;PROPAGATING; PRESERVING; OR MAINTAINING MICROORGANISMS;MUTATION OR GENETIC ENGINEERING;CULTURE MEDIA FOODS; FOODSTUFFS; OR NON-ALCOHOLIC BEVERAGES; NOT COVERED BY SUBCLASSES A21D OR A23B-A23J;THEIR PREPARATION OR TREATMENT; e.g. COOKING; MODIFICATION OF NUTRITIVE QUALITIES; PHYSICAL TREATMENT ;PRESERVATION OF FOODS OR FOODSTUFFS; IN GENERAL ENZYMES INDEXING SCHEME RELATING TO FOODS; FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
Examiner	Iqbal H Chowdhury
Extended Family	153-812-261-541-721 141-232-686-108-425 124-131-676-134-508 065-523-367-541-403 171-388-950-532-76X 139-146-606-417-971 175-741-690-350-82X 196-826-816-733-055 120-028-306-001-707 010-890-653-880-472 086-693-832-327-394 183-288-366-341-670 109-851-517-902-516 076-694-644-646-779 126-063-943-676-901 197-420-650-647-072
Patent ID	10494686
Inventor/Author	Lee Dong Woo Shin Sun Mi Lee Yong Jik Lee Sang Jae
IPC	A23L5/00 A23L27/30 A23L27/00 A23L29/30 C12N9/90 C12P19/02 C12P19/24
Status	Active
Owner	Kyungpook National University Industry-academic Cooperation Foundation Cj Cheiljedang Corporation
Simple Family	153-812-261-541-721 141-232-686-108-425 124-131-676-134-508 065-523-367-541-403 171-388-950-532-76X 139-146-606-417-971 175-741-690-350-82X 196-826-816-733-055 120-028-306-001-707 010-890-653-880-472 086-693-832-327-394 183-288-366-341-670 109-851-517-902-516 076-694-644-646-779 126-063-943-676-901 197-420-650-647-072
CPC (with Group)	C12P19/02 C12P19/24 C12N9/90 A23L29/30 A23L27/33 A23L5/00 C12Y501/03 C12Y501/03002 A23L27/30 C12Y503/03 A23V2002/00
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent/New European patent specification (amended specification after opposition procedure)