Systems and Methods of Discriminating Between A Control Sample and A Test Fluid Using Capacitance

Content Provider	The Lens
Related Links	https://www.lens.org/lens/patent/010-668-550-016-262/frontpage
Language	English
Publisher Date	2019-05-22
Access Restriction	Open
Alternative Title	Systeme Und Verfahren Zur Unterscheidung Zwischen Einer Kontrollprobe Und Einer Testflüssigkeit Anhand Von Kapazität Systèmes Et Procédés De Différenciation Entre Un Échantillon Témoin Et Un Fluide De Test Utilisant La Capacitance
Content Type	Text
Resource Type	Patent
Date Applied	2011-09-30
Agent	Carpmaels & Ransford Llp
Applicant	Cilag Gmbh Int
Application No.	11791045
Claim	A method for distinguishing between a blood sample and an aqueous non-blood sample, the method comprising: (a) applying a first test potential between a first electrode and a second electrode when a sample is introduced into an electrochemical cell and measuring a first current transient; (b) applying a second test potential between a first electrode and a second electrode, the second test potential being sufficient to oxidize a reduced mediator at the second electrode and measuring a second current transient; (c) measuring a capacitance of the electrochemical cell; (d) applying a third test potential between a first electrode and a second electrode, the third test potential being sufficient to oxidize a reduced mediator at the first electrode, and measuring a third current transient; (e) calculating, based on the first current transient, a first reference value; (f) calculating, based on the second and third current transients, a second reference value; (g) calculating, based on at least the measured capacitance, a capacitance index, which is a ratio of the measured capacitance and an average capacitance of electrochemical cells of the same type; (h) calculating, based on the first reference value and the capacitance index, a third reference value; and (i) determining, based on the second and third reference values, whether the sample is a blood sample or an aqueous non-blood sample. The method of claim 1, wherein the first reference value is calculated based upon at least one current value from the first current transient or upon a summation of current values measured during the first current transient. The method of claim 2, wherein the summation is represented by an equation, where t is a time and i sum is the summation of current values during a time interval from a time n to a time M. The method of claim 1, wherein the second reference value is based on a percent completion of a chemical reaction or upon at least one current value from the second current transient and at least one current value from the third current transient or upon a second current value at about the end of the second current transient and a third current value at about the beginning of the third current transient The method of claim 4, when the second reference value is based upon a second current value at about the end of the second current transient and a third current value at about the beginning of the third current transient, wherein the second reference value is based upon a ratio of the second current value and the third current value. The method of claim 1, further comprising the step of measuring a concentration of an analyte. The method of claim 6, wherein if the sample is found to be an aqueous non-blood sample the analyte concentration associated with the aqueous non-blood sample is flagged. The method of claim 1 , wherein step (i) further comprises using two inequalities to determine if the sample is an aqueous non-blood sample or a blood sample. The method of claim 1, wherein step (i) further comprises: comparing the second reference value to a pre-determined threshold equation; and comparing the third reference value to a pre-determined threshold value to determine if the sample is an aqueous non-blood sample or a blood sample. The method of claim 9, wherein the pre-determined threshold equation is a function of the third reference value. The method of claim 1, wherein the aqueous non-blood sample comprises a control sample. A system for distinguishing between a blood sample and an aqueous non-blood sample, the system comprising: a test strip (62) including electrical contacts (67) for mating with a test meter and an electrochemical cell comprising; a first electrode (66) and a second electrode (64) in a spaced apart relationship; and a reagent (72); and a test meter (100) including a processor adapted to receive current data from the test strip, and data storage containing discrimination criteria so that a blood sample can be distinguished from an aqueous non-blood sample based on a first reference value, a second reference value, and a capacitance index and in which the capacitance index is a ratio of an average capacitance of electrochemical cells of the same type and a measured capacitance of the electrochemical cel The system of claim 12, wherein the discrimination criteria is derived from a first reference value that is representative of antioxidant concentration and a second reference value that is representative of reaction kinetics. The system of claim 12, wherein the discrimination criteria includes an empirically derived discrimination line. The system of claim 12, wherein the capacitance index comprises a ratio of an average capacitance of electrochemical cells of the same type and a measured capacitance of the electrochemical cel The system of claim 12, wherein the aqueous non-blood sample is a control solution.
CPC Classification	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES; NUCLEIC ACIDS OR MICROORGANISMS ;COMPOSITIONS OR TEST PAPERS THEREFOR;PROCESSES OF PREPARING SUCH COMPOSITIONS;CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES Investigating Or Analysing Materials By Determining Their Chemical Or Physical Properties
Extended Family	037-739-024-217-270 022-876-001-760-728 045-239-843-147-80X 108-314-627-510-310 182-758-599-522-189 056-592-253-757-735 123-034-844-401-353 043-168-174-827-761 047-362-689-205-421 140-970-992-975-795 182-999-093-136-894 074-385-809-655-55X 114-502-628-429-958 145-010-007-476-51X 140-187-001-574-057 159-033-297-556-656 169-954-034-182-727 000-460-372-181-963 037-612-390-071-939 182-721-791-539-993 198-115-733-918-865 041-718-339-629-490 177-716-808-506-120 010-668-550-016-262 089-787-510-560-667 070-448-836-415-121 136-163-172-490-906 150-701-647-562-209
Patent ID	2622336
Inventor/Author	Chatelier Ronald C Hodges Alastair M
IPC	G01N27/327 C12Q1/00 G01N33/487
Status	Active
Owner	Cilag Gmbh International
Simple Family	037-739-024-217-270 022-876-001-760-728 045-239-843-147-80X 108-314-627-510-310 182-758-599-522-189 056-592-253-757-735 123-034-844-401-353 043-168-174-827-761 047-362-689-205-421 140-970-992-975-795 182-999-093-136-894 074-385-809-655-55X 114-502-628-429-958 145-010-007-476-51X 140-187-001-574-057 159-033-297-556-656 169-954-034-182-727 000-460-372-181-963 037-612-390-071-939 182-721-791-539-993 198-115-733-918-865 041-718-339-629-490 177-716-808-506-120 010-668-550-016-262 089-787-510-560-667 070-448-836-415-121 136-163-172-490-906 150-701-647-562-209
CPC (with Group)	C12Q1/005 G01N27/3274 G01N33/48707 G01N27/327 C12Q1/00 G01N33/487 G01N33/49 G01N27/26 G01N27/28
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent/Patent 1st level of publication/Inventor's certificate