Optical Method for Predicting Treatment Response, Survival and Recurrence of Esophageal Cancer Patients

Content Provider	The Lens
Abstract	The present invention provides an optical method for predicting treatment response, survival and recurrence of esophageal cancer patients, comprising analyzing the spectral signatures of patient's tumor tissue spectra. By the features of the present invention, the prediction result achieves the sensitivity of 75% and specificity of 73.3% in concurrent chemoradiotherapy (CCRT) response; the survival prediction rate achieves the sensitivity of 100%; the recurrence prediction rate achieves the sensitivity of 85.7%.
Related Links	https://www.lens.org/lens/patent/009-911-048-505-476/frontpage
Language	English
Publisher Date	2019-01-17
Access Restriction	Open
Content Type	Text
Resource Type	Patent
Jurisdiction	United States of America
Date Applied	2017-09-13
Applicant	Univ Nat Taiwan
Application No.	201715703941
Claim	An optical method for predicting treatment response of esophageal cancer patients, comprising: obtaining an optical absorption spectrum of a tumor tissue sample from an esophageal cancer patient, the optical absorption spectrum of the tumor tissue sample is a visible optical absorption spectrum; normalizing the optical absorption spectrum of the tumor tissue sample, incorporating into a pre-stored database and grouping by a principal component analysis; wherein a plural of spectral variables of principal component analysis are obtained from wavelength of 450-475 nm and 625-650 nm; and grouping all the spectra by PC_7 and PC_2 value of the principal component analysis to determine the esophageal cancer patient is identified as having good response or poor response to the treatment; wherein the treatment is concurrent chemoradiotherapy. The optical method according to claim 1 , wherein the optical absorption spectrum of the tumor tissue sample is an optical absorption spectrum captured by a wavelength from 450 to 650 nm. The optical method according to claim 1 , wherein the optical absorption spectrum of the tumor tissue sample is a transmission absorption spectrum. The optical method according to claim 1 , wherein the pre-stored database is pre-stored an effective amount of normalized optical absorption spectra of tumor tissue samples. An optical method for predicting survival of esophageal cancer patients, comprising: obtaining an optical absorption spectrum of a tumor tissue sample from an esophageal cancer patient, the optical absorption spectrum of the tumor tissue sample is a visible optical absorption spectrum; normalizing the optical absorption spectrum of the tumor tissue sample, incorporating into a pre-stored database and grouping by a principal component analysis; wherein a plural of spectral variables of principal component analysis are obtained from wavelength of 450-475 nm and 625-650 nm; and grouping all the spectra by PC_1 and PC_3 value of the principal component analysis to determine the esophageal cancer patient is identified as poor survival or non-poor surviva The optical method according to claim 5 , wherein the poor survival defined as the esophageal cancer patient is alive within 1 year, and the non-poor survival defined as the esophageal cancer patient is alive over 1 year. The optical method according to claim 5 , wherein the optical absorption spectrum of the tumor tissue sample is an optical absorption spectrum captured by a wavelength from 450 to 650 nm. The optical method according to claim 6 , wherein the optical absorption spectrum of the tumor tissue sample is an optical absorption spectrum captured by a wavelength from 450 to 650 nm. The optical method according to claim 5 , wherein the optical absorption spectrum of the tumor tissue sample is a transmission absorption spectrum. The optical method according to claim 6 , wherein the optical absorption spectrum of the tumor tissue sample is a transmission absorption spectrum. The optical method according to claim 5 , wherein the pre-stored database is pre-stored an effective amount of normalized optical absorption spectra of tumor tissue samples. The optical method according to claim 6 , wherein the pre-stored database is pre-stored an effective amount of normalized optical absorption spectra of tumor tissue samples. An optical method for predicting recurrence of esophageal cancer patients, comprising: obtaining an optical absorption spectrum of a tumor tissue sample from an esophageal cancer patient, the optical absorption spectrum of the tumor tissue sample is a visible optical absorption spectrum; normalizing the optical absorption spectrum of the tumor tissue sample, incorporating into a pre-stored database and grouping by a principal component analysis; wherein a plural of spectral variables of principal component analysis are obtained from wavelength of 450-475 nm and 625-650 nm; and grouping all the spectra by PC_6 and PC_5 value of principal component analysis to determine the esophageal cancer patient is identified as recurrence or no recurrence. The optical method according to claim 13 , wherein the recurrence defined as the esophageal cancer patient experience tumor recurrence or die within 6 months and the no recurrence defined as the esophageal cancer patient wouldn't experience tumor recurrence within 6 months. The optical method according to claim 13 , wherein the optical absorption spectrum of the tumor tissue sample is an optical absorption spectrum captured by a wavelength from 450 to 650 nm. The optical method according to claim 14 , wherein the optical absorption spectrum of the tumor tissue sample is an optical absorption spectrum captured by a wavelength from 450 to 650 nm. The optical method according to claim 13 , wherein the optical absorption spectrum of the tumor tissue sample is a transmission absorption spectrum. The optical method according to claim 14 , wherein the optical absorption spectrum of the tumor tissue sample is a transmission absorption spectrum. The optical method according to claim 13 , wherein the pre-stored database is pre-stored an effective amount of normalized optical absorption spectra of tumor tissue samples. The optical method according to claim 14 , wherein the pre-stored database is pre-stored an effective amount of normalized optical absorption spectra of tumor tissue samples.
CPC Classification	Investigating Or Analysing Materials By Determining Their Chemical Or Physical Properties Healthcare Informatics; I.E. Information And Communication Technology [Ict] Specially Adapted For The Handling Or Processing Of Medical Or Healthcare Data
Extended Family	182-440-201-519-95X 014-065-045-518-299 009-911-048-505-476 108-410-101-560-225
Patent ID	20190017925
Inventor/Author	Lee Jang-ming Hsu I-jen Hou Max Ti-kuang Yang Pei-wen
IPC	G01N21/31 G01N33/574
Status	Active
Owner	National Taiwan University
Simple Family	182-440-201-519-95X 014-065-045-518-299 009-911-048-505-476 108-410-101-560-225
CPC (with Group)	G01N21/31 G01N2201/1293 G01N2800/52 G16H20/10 G16H20/40 G16H50/30 G16H50/70 G01N33/574 G01N2021/1742
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent Application Publication