Method for Inducing Antitumor Immunity Using Sindbis Viral Vectors and Tumor Associated Antigens

Content Provider	The Lens
Abstract	The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (TAA) expressed by the tumor and parenterally administering to the mammal a therapeutically effective amount of a Sindbis viral vector carrying a gene encoding the TAA to the mammal sufficient to elicit an immune response directed against the tumor, and thereby treating the tumor.
Related Links	https://www.lens.org/lens/patent/009-456-069-900-326/frontpage
Language	English
Publisher Date	2019-01-03
Access Restriction	Open
Content Type	Text
Resource Type	Patent
Jurisdiction	United States of America
Date Applied	2018-06-01
Applicant	Univ New York
Application No.	201815996271
Claim	- 22 . (canceled) An immunogenic composition formulated for parenteral delivery, comprising a Sindbis viral vector containing a polynucleotide encoding NY-ESO-1, wherein the Sindbis viral vector is present in an amount sufficient to elicit an anti-tumor immune response in a lymph node and to cause epitope spreading when administered to a subject; and wherein the Sindbis viral vector does not directly target a tumor cell of the subject. The immunogenic composition of claim 23 , wherein the elicited anti-tumor immune response is a CD8+ T cell mediated immune response directed against the cells of the tumor. The immunogenic composition of claim 23 , wherein the Sindbis viral vector infects the lymph nodes and the infection is followed by induction of T cell activation. The immunogenic composition of claim 23 , wherein the Sindbis viral vector is replication defective. The immunogenic composition of claim 23 , wherein the Sindbis viral vector is replication competent. The immunogenic composition of claim 23 , wherein the subject is a human. The immunogenic composition of claim 23 , wherein the tumor is a solid tumor. The immunogenic composition of claim 23 , which is a dual expression Sindbis viral vector containing the polynucleotide encoding NY-ESO-1 and a polynucleotide encoding an immune stimulating cytokine selected from interleukin-12 (IL-12) or CCL17. The immunogenic composition of claim 23 , which further comprises a polynucleotide encoding a cytokine selected from the group consisting of interleukin-1 (IL-1) through interleukin-36 (IL-36), chemokine (C-C motif) ligand 1 (CCL1) through chemokine (C-C motif) ligand 27 (CCL27), chemokine (C-X-C motif) ligand 1 (CXCLI) through chemokine (C-X-C motif) ligand 13 (CXCL13), and chemokine (C-X3-C motif) (CX3C). The immunogenic composition of claim 29 , wherein the solid tumor is an ovarian tumor. The immunogenic composition of claim 23 , wherein the parenteral delivery is selected from intraperitoneal, intravenous, or subcutaneous delivery. The immunogenic composition of claim 23 , further comprising a pharmaceutically acceptable excipient, vehicle, or diluent. A method of inducing an anti-tumor immune response in a subject, the method comprising administering to the subject an effective amount of the immunogenic composition of claim 34 . The method of claim 35 , wherein the method treats the tumor. The method of claim 35 , wherein the tumor is a NY-ESO-1-expressing tumor. The method of claim 37 , wherein the tumor is an ovarian tumor.
CPC Classification	Preparations For Medical; Dental Or Toiletry Purposes MICROORGANISMS OR ENZYMES;COMPOSITIONS THEREOF;PROPAGATING; PRESERVING; OR MAINTAINING MICROORGANISMS;MUTATION OR GENETIC ENGINEERING;CULTURE MEDIA Specific Therapeutic Activity Of Chemical Compounds Or Medicinal Preparations
Extended Family	007-025-137-784-578 160-259-444-769-393 155-224-046-880-685 092-519-782-124-516 067-969-442-892-772 076-627-629-594-798 135-227-590-630-08X 156-798-941-264-773 136-105-702-361-226 004-359-940-436-151 006-773-335-681-905 169-305-648-037-874 009-456-069-900-326 134-564-681-578-791 077-922-380-291-684 125-063-343-003-635 046-975-884-709-17X 060-598-039-658-850 035-284-063-807-926 195-571-066-625-419 066-766-583-276-272
Patent ID	20190000994
Inventor/Author	Meruelo Daniel Granot Tomer Yamanashi Yoshihide
IPC	A61K48/00 A61K39/00
Status	Discontinued
Owner	New York University
Simple Family	007-025-137-784-578 160-259-444-769-393 155-224-046-880-685 092-519-782-124-516 067-969-442-892-772 076-627-629-594-798 135-227-590-630-08X 156-798-941-264-773 136-105-702-361-226 004-359-940-436-151 006-773-335-681-905 169-305-648-037-874 009-456-069-900-326 134-564-681-578-791 077-922-380-291-684 125-063-343-003-635 046-975-884-709-17X 060-598-039-658-850 035-284-063-807-926 195-571-066-625-419 066-766-583-276-272
CPC (with Group)	A61K39/0011 A61K2039/5256 A61K2039/572 C12N2770/36143 A61P15/00 A61P35/00 A61P37/04 A61P43/00 A61K39/001182 A61K39/001188 A61K48/0058
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent Application Publication