Systems and Methods to Infer Brain State During Burst Suppression

Content Provider	The Lens
Abstract	Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.
Related Links	https://www.lens.org/lens/patent/009-136-411-133-247/frontpage
Language	English
Publisher Date	2019-08-20
Access Restriction	Open
Content Type	Text
Resource Type	Patent
Jurisdiction	United States of America
Date Applied	2014-06-27
Agent	Quarles & Brady Llp
Applicant	Purdon Patrick L Brown Emery N Lewis Laura D Westover Brandon M Ching Shinung Massachusetts Gen Hospital
Application No.	201414318277
Claim	A system for monitoring a subject, the system comprising: a plurality of electroencephalogram (EEG) sensors configured to acquire EEG signals from multiple locations about a subject's brain; an input configured to receive at least the EEG signals from the plurality of EEG sensors; a processor in communication with the input and configured to: i) receive the EEG signals from the input; ii) assemble a set of time-series data using the EEG signals received; iii) analyze the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state; iv) identify a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified in (iii), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject's brain; v) compare the burst characteristic profile against a reference set of burst profiles; and vi) determine, based on the comparison of (v), a likelihood of a brain state of the subject underlying the burst suppression state; and a display configured to provide a report, generated by the processor, indicating the likelihood of the brain state determined in (vi). The system of claim 1 , wherein the processor is further configured to apply a segmentation algorithm to identify the epochs in the set of time-series data. The system of claim 1 , wherein the burst characteristic profile includes a burst spectral content. The system of claim 1 , wherein the processor is further configured to determine at least one of a burst timing pattern and a spatial pattern using the burst activity across the subject's brain. The system of claim 1 , wherein the reference set of burst profiles is related to a non-burst suppression state. The system of claim 1 , wherein the processor is further configured to generate and provide an indication in relation to a future brain state of the subject upon recovery from the burst suppression state. The system of claim 1 , further comprising a controller for controlling a future brain state of the subject using the determined brain state. The system of claim 1 , wherein the display is further configured to indicate a burst cluster illustrative of concurrent burst activity across the subject's brain. A method for monitoring a subject comprising steps of: (a) acquiring electroencephalogram (EEG) signals from multiple locations about a subject's brain using a plurality of EEG sensors positioned thereabout; and using a processor (b) assembling a set of time-series data using the EEG signals acquired; (c) analyzing the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state; (d) identifying a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified at step (c), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject's brain; (e) comparing the burst characteristic profile against a reference set of burst profiles; (f) determining, based on the comparison of step (e), a likelihood of a brain state of the subject underlying the burst suppression state; and (g) generating a report indicative of the likelihood of the brain state determined in step (f). The method of claim 9 , the method further comprising applying a segmentation algorithm to identify the epochs of the set of time-series data. The method of claim 9 , wherein the burst characteristic profile includes a burst spectral content. The method of claim 9 , the method further comprising determining at least one of a burst timing pattern and a spatial pattern using the burst activity across the subject's brain. The method of claim 9 , wherein the reference set of burst profiles is related to a non-burst suppression state. The method of claim 9 , the method further comprising providing an indication in relation to a future state of the subject upon recovery from the burst suppression state. The method of claim 9 , the method further comprising indicating a burst cluster illustrative of concurrent burst activity across the a subject's brain. The method of claim 9 , the method further comprising controlling a future brain state of the subject using the determined brain state.
CPC Classification	Diagnosis; Surgery; Identification
Examiner	Etsub D Berhanu
Extended Family	009-136-411-133-247 023-304-112-443-20X 039-100-916-084-86X 051-744-098-341-577
Patent ID	10383574
Inventor/Author	Purdon Patrick L Brown Emery N Lewis Laura D Westover Brandon M Ching Shinung
IPC	A61B5/0476 A61B5/00 A61B5/04 A61B5/0478
Status	Active
Owner	The General Hospital Corporation
Simple Family	009-136-411-133-247 023-304-112-443-20X 039-100-916-084-86X 051-744-098-341-577
CPC (with Group)	A61B5/6814 A61B5/291 A61B5/4064 A61B5/4821 A61B5/4839 A61B5/293
Issuing Authority	United States Patent and Trademark Office (USPTO)
Kind	Patent/New European patent specification (amended specification after opposition procedure)